解剖学杂志2025，Vol.48Issue(3)：241-245,5.DOI:10.3969/j.issn.1001-1633.2025.03.010
GLI锌指3基因单核苷酸多态性与指长比(D2/4)的关联性
Association between GLI zinc finger 3 gene single nucleotide polymorphisms and the second to fourth digit ratio(D2/4)
摘要
Abstract
Objective:To explore the association between single nucleotide polymorphisms(SNPs)in five loci(rs77640775,rs2051935,rs3823720,rs1125413,rs846266)of GLI zinc finger 3 gene(GLI3)and the second to fourth digit ratio(D2/4).Methods:A total of 807 college students(405 females and 402 males)of Han nationality in Ningxia were selected as subjects.Photos of both hands were captured using a digital camera,and then the length of the index finger(2D)and ring finger(4D)were measured respectively by the Image-Pro Plus 6.0 software.Multiplex PCR assays were used to detect the genotype of 5 SNP sites of GLI3 gene.The relationship between D2/4 and GLI3 gene polymorphisms was evaluated by one-way analysis of variance.Results:The left hand D2/4(LD2/4)and right hand D2/4(RD2/4)were significantly higher in female university students in Ningxia than those in males.There were no statistically significant differences in genotype and distribution of allele frequencies in the five loci of GLI3 gene between males and females.There was no significant association between the five loci SNPs of the GLI3 gene and the digit ratio(D2/4)of both hands among different genders.Conclusion:There are significant gender differences of D2/4 in the university students in Ningxia,and polymorphism in the GLI3 loci have not yet been found to be associated with the formation of D2/4.关键词
GLI3基因/单核苷酸多态性/示-环指长比(D2/4)Key words
GLI zinc finger 3 gene/single nucleotide polymorphism/second to fourth digit ratio分类
生物科学引用本文复制引用
沈丹,杨梦怡,张静,牛世博,马占兵,党洁,陆宏,霍正浩,徐彧..GLI锌指3基因单核苷酸多态性与指长比(D2/4)的关联性[J].解剖学杂志,2025,48(3):241-245,5.基金项目
国家自然科学基金(32160211,31960195) （32160211,31960195）
