实用临床医药杂志2025，Vol.29Issue(11)：20-25,6.DOI:10.7619/jcmp.20245856
富血小板血浆治疗糖尿病足溃疡的荟萃分析
A meta-analysis of platelet-rich plasma for treatment of diabetic foot ulcers
摘要
Abstract
Objective To evaluate the clinical efficacy of platelet-rich plasma(PRP)in treat-ment of diabetic foot ulcers(DFU)using a meta-analysis approach.Methods Relevant literature on PRP for treatment of DFU was collected by searching databases including PubMed,Cochrane Library,Embase,Web of Science,NEJM,CNKI,Wanfang Data,VIP Database,and China Biology Medicine disc.Relevant literature on PRP for treatment of DFU was collected.The literature was read,and effect sizes were extracted.The extracted data were then subjected to a meta-analysis using RevMan 5.3 software.Results A total of 6 studies were included in this meta-analysis,involving 440 pa-tients.Among them,there were 208 patients in experimental group(PRP combined with conventional treatment)and 232 patients in control group(conventional treatment,blank control,or placebo treat-ment).The ulcer healing efficacy rate in the experimental group was higher than that in the control group(OR=1.29,95％CI,1.19 to 1.40,P＜0.05).The incidence of adverse reactions in the experimental group was lower than that in the control group(OR=0.33,95％CI,0.12 to 0.93,P=0.94).The healing time(MD=-14.37,95％CI,-23.12 to-5.62,P=0.001),thickness of granulation tissue on the ulcer surface(MD=1.60,95％CI,1.31-1.88,P＜0.000 01),coverage rate of granulation tissue on ulcer surface(MD=6.03,95％CI,3.79 to 8.26,P＜0.05),and level of vascular endothelial growth factor on the ulcer surface(MD=7.62,95％CI,1.57 to 13.67,P=0.01)in the experimental group were all superior to those in the control group.Con-clusion PRP treatment for DFU has the advantages of improving the ulcer healing efficacy rate,shortening the ulcer healing time,promoting the growth of granulation tissue on the ulcer surface,and reducing the incidence of adverse reactions.关键词
富血小板血浆/糖尿病足溃疡/药物相关不良反应/肉芽组织/荟萃分析/肉芽组织厚度/血管内皮生长因子/肉芽组织覆盖率Key words
platelet-rich plasma/diabetic foot ulcer/drug-related adverse reactions/granu-lation tissue/meta-analysis/thickness of granulation tissue/vascular endothelial growth factor/cov-erage rate of granulation tissue分类
医药卫生引用本文复制引用
王宇泽,梁浩,苏燕,丁海麦,侯晓蒙,刘治..富血小板血浆治疗糖尿病足溃疡的荟萃分析[J].实用临床医药杂志,2025,29(11):20-25,6.基金项目
内蒙古自然科学基金项目(2022QN08018) （2022QN08018）
内蒙古自治区高等学校科学研究项目(NJZZ22063) （NJZZ22063）
内蒙古自治区包头市卫生健康科技计划项目(wsjkkj029) （wsjkkj029）
包头医学院科学研究基金项目(BYJJ-BSJJ 202002) （BYJJ-BSJJ 202002）
包头医学院花蕾计划项目(HLJH20240) （HLJH20240）
