实用临床医药杂志2025，Vol.29Issue(11)：26-32,41,8.DOI:10.7619/jcmp.20246109
心脏骤停患者复苏成功后院内死亡的风险预测模型构建及验证
Construction and validation of a risk prediction model for in-hospital death after successful resuscitation in patients with cardiac arrest
摘要
Abstract
Objective To construct and validate a risk prediction model for in-hospital death af-ter successful resuscitation in patients with cardiac arrest.Methods A retrospective study was con-ducted on 295 patients with cardiac arrest who successfully restored spontaneous circulation after car-diopulmonary resuscitation and were further treated in hospital.The patients were divided into training and validation sets using K-fold cross-validation and then grouped and compared based on whether in-hospital death occurred.A binary Logistic regression analysis was used to screen risk prediction fac-tors,and a nomogram prediction model was constructed.The model performance was evaluated and validated in the training and validation sets,respectively.Results The results of the multivariate Logistic regression analysis showed that hospitalization duration(OR=1.180;95％CI,1.080 to 1.280;P＜0.001),norepinephrine dose(OR=0.980;95％CI,0.970 to 0.990;P=0.002),ini-tial respiratory rate after resuscitation(OR=1.090;95％CI,1.030 to 1.150;P=0.004),and sinus rhythm recovery after resuscitation(OR=4.280;95％CI,1.670 to 10.980;P=0.003)were inde-pendent influencing factors for in-hospital death.A nomogram model was constructed based on these in-dependent influencing factors,and it was verified that the model had good discrimination,calibration,applicability,and rationality.Conclusion The influencing factors for in-hospital death after successful resuscitation in patients with cardiac arrest include hospitalization duration,norepinephrine dose,initial respiratory rate after resuscitation,and sinus rhythm recovery after resuscitation.The nomo-gram model constructed based on these factors can provide a reference for clinical decision-making.关键词
心脏骤停/心源性猝死/心肺复苏/自主循环恢复/院内死亡/列线图模型/窦性心律/去甲肾上腺素Key words
cardiac arrest/sudden cardiac death/cardiopulmonary resuscitation/return of spontaneous circulation/in-hospital death/nomogram model/sinus rhythm/norepinephrine分类
医药卫生引用本文复制引用
李玉,陈阵,郭鑫,梁依凡,王珏艳,李锦磊,杨先婷,艾芬..心脏骤停患者复苏成功后院内死亡的风险预测模型构建及验证[J].实用临床医药杂志,2025,29(11):26-32,41,8.基金项目
湖北省科技厅自然科学基金资助项目(2024AFB893) （2024AFB893）
