实用临床医药杂志2025，Vol.29Issue(11)：55-60,6.DOI:10.7619/jcmp.20244171
血浆致动脉粥样硬化指数预测非酒精性脂肪性肝病患者冠心病风险的价值
Value of atherosclerotic index of plasma in predicting risk of coronary heart disease in patients with nonalcoholic fatty liver disease
摘要
Abstract
Objective To investigate the predictive value of atherosclerotic index of plasma(AIP)for the risk of coronary heart disease(CHD)in patients with nonalcoholic fatty liver disease(NAFLD).Methods A retrospective analysis was conducted in 299 patients with NAFLD.Based on presence or absence of CHD,the patients were divided into NAFLD with CHD group(n=177)and NAFLD group(n=122).Clinical data were collected from both groups,and AIP was calculat-ed.Multivariate Logistic regression analysis was performed to explore the independent risk factors for CHD in patients with NAFLD.Receiver operating characteristic(ROC)curves were plotted to evalu-ate the predictive value of AIP for the risk of CHD in patients with NAFLD.Results The NAFLD with CHD group had a higher proportion of males,smokers,and higher levels of alanine aminotrans-ferase(ALT),aspartate aminotransferase(AST),fasting plasma glucose(FPG),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),γ-glutamyltransferase(GGT),uric acid(UA),and AIP than the NAFLD group.The NAFLD with CHD group also had lower levels of high-density lipoprotein cholesterol(HDL-C)than the NAFLD group(P＜0.05).Multivariate Logistic regression analysis revealed that males(OR=2.548,95％CI,1.402 to 4.632,P=0.002),high levels of AST(OR=1.038,95％CI,1.002 to 1.077,P=0.041),high levels of LDL-C(OR=1.811,95％CI,1.242 to 2.640,P=0.002),and high AIP(OR=16.117,95％CI,1.874 to 138.609,P=0.011)were independent risk factors for CHD in patients with NAFLD(P＜0.05).ROC curve analysis showed that AIP had an area under the curve of 0.746(95％CI,0.688 to 0.804)for pre-dicting CHD in patients with NAFLD,with a sensitivity of 76.3％and a specificity of 73.0％.Conclusion AIP is an independent influencing factor for CHD in patients with NAFLD and has certain predictive value for the risk of CHD in these patients.关键词
非酒精性脂肪性肝病/血浆致动脉粥样硬化指数/冠心病/冠状动脉造影/谷草转氨酶/低密度脂蛋白胆固醇/风险因素/预测价值Key words
nonalcoholic fatty liver disease/atherosclerotic index of plasma/coronary heart disease/coronary arteriography/aspartate aminotransferase/low-density lipoprotein cholesterol/risk factors/predictive value分类
医药卫生引用本文复制引用
袁淑敏,欧阳小芳,秦浩,李东升,占婷,刘蒙,韩峥,田霞..血浆致动脉粥样硬化指数预测非酒精性脂肪性肝病患者冠心病风险的价值[J].实用临床医药杂志,2025,29(11):55-60,6.基金项目
湖北省武汉市知识创新专项曙光计划项目(2022020801020552) （2022020801020552）
