实用临床医药杂志2025，Vol.29Issue(12)：13-18,6.DOI:10.7619/jcmp.20245273
脑脊液SNAP-25与NEAT1联合检测对阿尔茨海默病患者认知障碍程度评价及病情进展预测的价值
Value of combined detection of cerebrospinal fluid SNAP-25 and NEAT1 in evaluating degree of cognitive impairment and predicting disease progression in patients with Alzheimer's disease
摘要
Abstract
Objective To evaluate value of combined detection of cerebrospinal fluid synaptosom-al-associated protein 25(SNAP-25)and long non-coding RNA nuclear-enriched transcript 1(NEAT1)in assessing cognitive impairment severity and disease progression in patients with Alzhei-mer's disease.Methods A total of 650 patients with Alzheimer's disease were selected as research subjects and divided into normal group(n=162),mild cognitive impairment group(n=380)and dementia group(n=108)according to their cognitive function.The correlations of the levels of SNAP-25 and NEAT1 in cerebrospinal fluid with the scores of Mini-Mental State Examination(MMSE)and Clinical Dementia Rating Scale(CDR)were analyzed.According to whether the patients in the mild cognitive impairment group progressed to dementia(followed up for 6 months),they were divided into disease progression group(progressed to dementia)and stable disease group(did not progress to dementia).The levels of SNAP-25 and NEAT1 in cerebrospinal fluid of patients in each group were compared.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of cerebrospinal fluid SNAP-25 combined with NEAT1 for dementia and its predictive efficacy for the progression of mild cognitive impairment to dementia.Results The levels of SNAP-25 and NEAT1 mRNA in cerebrospinal fluid in the mild cognitive impairment group and the dementia group were significantly higher than those in the normal group;the levels of cerebrospinal fluid SNAP-25 and NEAT1 mRNA in the dementia group were significantly higher than those in the mild cognitive impairment group(P＜0.05).The levels of cerebrospinal fluid SNAP-25 and NEAT1 mRNA in pa-tients of the mild cognitive impairment group and the dementia group were negatively correlated with the MMSE score(P＜0.05),and positively correlated with the CDR score(P＜0.05).In the mild cognitive impairment group,133 patients' conditions progressed from mild cognitive impairment to dementia.The levels of cerebrospinal fluid SNAP-25 and NEAT1 mRNA in the disease progres-sion group were significantly higher than those in the stable disease group(P＜0.05).ROC curve analysis showed that the sensitivity of cerebrospinal fluid SNAP-25 combined with NEAT1 in diagno-sing dementia was 89.63％,the specificity was 54.08％,and the area under the curve(AUC)was 0.884.The sensitivity of cerebrospinal fluid SNAP-25 combined with NEAT1 in predicting the pro-gression of mild cognitive impairment to dementia was 83.41％,the specificity was 56.70％,and the AUC was 0.867.Conclusion The levels of SNAP-25 and NEAT1 in cerebrospinal fluid in-crease significantly with the aggravation of cognitive impairment in patients with Alzheimer's dis-ease.The combined detection of SNAP-25 and NEAT1 has relatively high diagnostic efficacy for de-mentia and predictive value for the progression from mild cognitive impairment to dementia.关键词
阿尔茨海默病/认知障碍/脑脊液/突触小体相关蛋白-25/长链非编码RNA核富集转录本1/痴呆/病情进展/诊断效能Key words
Alzheimer's disease/cognitive impairment/cerebrospinal fluid/synaptosomal-associated protein 25/Long non-coding RNA nucleo-enriched transcript 1/dementia/disease pro-gression/diagnostic efficiency分类
医药卫生引用本文复制引用
时誉,句晓慧,王奇,李琴,何俐..脑脊液SNAP-25与NEAT1联合检测对阿尔茨海默病患者认知障碍程度评价及病情进展预测的价值[J].实用临床医药杂志,2025,29(12):13-18,6.基金项目
自治区重点实验室新疆神经系统疾病研究重点实验室开放课题(XJDX1711-2273) （XJDX1711-2273）
