军事医学2025，Vol.49Issue(6)：465-472,8.DOI:10.7644/j.issn.1674-9960.2025.06.010
胱天蛋白酶在程序性细胞死亡中作用机制研究进展
Advances in roles of caspases in programmed cell death
摘要
Abstract
The caspase family is a conserved cysteine protease with similar amino acid sequences,structures and enzyme characteristics.Caspase is a single polypeptide with a molecular weight of 30-50 kDa,which is composed of three domains:the N-terminal pre-domain,the large submit of 20 kDa and the small submit of 10 kDa.Programmed cell death plays a pivotal role in bodily immune responses to infections byclearing infected cells,activating immune responses of cells and regulating the balance of immune cells,so it is one of the important mechanisms through which the body resists pathogens.The activation and regulation of the caspase family are critical to programmed cell death.This article reviews the latest research progress in caspase activation and its mechanism in programmed cell death.关键词
胱天蛋白酶/细胞死亡/凋亡/焦亡/程序性坏死Key words
caspase/cell death/apoptosis/pyroptosis/programmed necrosis分类
医药卫生引用本文复制引用
胡玉茹,李崭,李涛,王慧..胱天蛋白酶在程序性细胞死亡中作用机制研究进展[J].军事医学,2025,49(6):465-472,8.基金项目
北京市自然科学基金项目(M23001) （M23001）
