昆明医科大学学报2025，Vol.46Issue(7)：1-9,9.DOI:10.12259/j.issn.2095-610X.S20250701
脂肪组织线粒体功能在肥胖中的作用
The Role of Mitochondrial Function in Adipose Tissue in Obesity
摘要
Abstract
Obesity has become a major global public health issue,and the situation in China is also becoming increasingly severe.Adipose tissue is categorized into white adipose tissue(WAT)and brown adipose tissue(BAT),which regulates metabolic homeostasis by secreting various adipokines.Mitochondria,as the core organelles of energy metabolism,its dysfunction are closely related to obesity.In the state of obesity,mitochondrial dynamics imbalance,oxidative stress,and metabolic dysfunction can all lead to energy metabolism disorders and adipose tissue dysfunction.Moreover,mitochondrial dysfunction not only affects adipose tissue but also extends to multiple organs such as muscles and livers,thereby exacerbating obesity and related metabolic diseases.In recent years,although numerous therapeutic strategies targeting mitochondrial dysfunction have been actively explored,their clinical translation faces challenges.This review explores the association between mitochondrial dysfunction in adipose tissue and obesity,analyses its mechanism and existing treatment strategies,aiming to provide a new perspective for the diagnosis and treatment of obesity.关键词
肥胖/脂肪组织/线粒体功能障碍/代谢紊乱Key words
Obesity/Adipose tissue/Mitochondrial dysfunction/Metabolic disorders分类
医药卫生引用本文复制引用
钱映,杨寄镯,黄娟,袁科迪,刘俊仪,冯月梅,殷建忠..脂肪组织线粒体功能在肥胖中的作用[J].昆明医科大学学报,2025,46(7):1-9,9.基金项目
国家自然科学基金(82260641,81860597) （82260641,81860597）
云南省基础研究专项计划重点项目(202501AS070132) （202501AS070132）
云南省高校服务重点产业科技项目(博士生服务产业科研创新培育项目,FWCY-BSPY2024079) （博士生服务产业科研创新培育项目,FWCY-BSPY2024079）
昆明医科大学一流学科特色团队(2024XKTDTS15) （2024XKTDTS15）
云南省赵星专家工作站(202505AF350064) （202505AF350064）
