临床传统医学和药理学（英文）2025，Vol.6Issue(2)：25-34,10.DOI:10.1016/j.ctmp.2025.200203
芝麻酚可能通过与环氧化酶的相互作用在肉仔鸡体内发挥与塞来昔布和酮洛芬的协同抗炎作用
Sesamol exerts' anti-inflammatory effect and synergistic properties with celecoxib and ketoprofen in broiler chicks possibly through COXs interaction pathway
Tahajul Islam 1Irfan Aamer Ansari 2Davi Antas e Silva 3Henrique Douglas Melo Coutinho 4Muhammad Torequl Islam 5Raihan Chowdhury 6Shimul Bhuia 7Showkoth Akbor 1Mehedi Hasan Bappi 8Rubel Hasan 6Salehin Sheikh 6Touhidul Islam Tanim 1Siddique Akber Ansari9
作者信息
- 1. Department of Pharmacy,Gopalganj Science and Technology University,Gopalganj 8100,Bangladesh
- 2. Department of Drug Science and Technology University of Turin,Turin 10124,Italy
- 3. Federal University of Paraíba,Campus Ⅰ Lot.Cidade Universitaria,João Pessoa,PB 58051-900,Brazil
- 4. Laboratory of Microbiology and Molecular Biology(LMBM),Department of Biological Chemistry-URCA,Crato,CE 63105-000,Brazil
- 5. Department of Pharmacy,Gopalganj Science and Technology University,Gopalganj 8100,Bangladesh||Bioinformatics and Drug Innovation Laboratory,Bioluster Research Center Ltd.,Gopalganj 8100,Dhaka,Bangladesh||Pharmacy Discipline,Khulna University,Khulna 9208,Bangladesh
- 6. Department of Pharmacy,Gopalganj Science and Technology University,Gopalganj 8100,Bangladesh||Bioinformatics and Drug Innovation Laboratory,Bioluster Research Center Ltd.,Gopalganj 8100,Dhaka,Bangladesh
- 7. Bioinformatics and Drug Innovation Laboratory,Bioluster Research Center Ltd.,Gopalganj 8100,Dhaka,Bangladesh
- 8. Bioinformatics and Drug Innovation Laboratory,Bioluster Research Center Ltd.,Gopalganj 8100,Dhaka,Bangladesh||School of Pharmacy,Jeonbuk National University,Jeonju 54896,Republic of Korea
- 9. Department of Pharmaceutical Chemistry,College of Pharmacy,King Saud University,Riyadh 11451,Saudi Arabia
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摘要
Abstract
Background:Inflammation is a complex process with significant implications for animal health.Sesamol(SEL),a phenolic lignan from Sesamum indicum L.,possesses various health benefits.
Objective:To assess the anti-inflammatory effects of SEL alone and in combination with celecoxib(CXB)and ketoprofen(KPN)in a broiler chick model of inflammation,and to explore the molecular interactions of SEL with cyclooxygenase(COX)enzymes using in silico analysis.
Methods:Inflammation was induced in broiler chicks via sub-plantar injection of 0.5％formaldehyde.Animals were treated orally with SEL(25 mg/kg,50 mg/kg,and 100 mg/kg),CXB(42 mg/kg),KPN(42 mg/kg),or com-binations of SEL either with CXB or KPN.Paw licking frequency and edema size were measured.Computational docking studies were performed to investigate SEL's binding affinity to COX-1 and COX-2.
Results:SEL significantly(P＜0.05)and dose-dependently reduced paw licking frequency and edema size.The combination of SEL with CXB showed a greater anti-inflammatory effect than the combination with KPN.In silico analysis revealed a higher binding affinity of SEL for COX-2(-6.1 kcal/mol)compared to COX-1(-5.8 kcal/mol).
Conclusion:SEL exhibits anti-inflammatory activity and demonstrates synergistic effects with CXB and KPN in vivo.These effects are likely mediated through interactions with both COX-1 and COX-2 enzymes,with a preference for COX-2.These findings suggest SEL as a potential therapeutic agent for inflammation.关键词
环氧化酶/炎症/芝麻酚/分子对接/药理学Key words
Cyclooxygenase enzyme/Inflammation/Sesamol/Molecular docking/Pharmacology引用本文复制引用
Tahajul Islam,Irfan Aamer Ansari,Davi Antas e Silva,Henrique Douglas Melo Coutinho,Muhammad Torequl Islam,Raihan Chowdhury,Shimul Bhuia,Showkoth Akbor,Mehedi Hasan Bappi,Rubel Hasan,Salehin Sheikh,Touhidul Islam Tanim,Siddique Akber Ansari..芝麻酚可能通过与环氧化酶的相互作用在肉仔鸡体内发挥与塞来昔布和酮洛芬的协同抗炎作用[J].临床传统医学和药理学（英文）,2025,6(2):25-34,10.
