临床传统医学和药理学（英文）2025，Vol.6Issue(2)：44-52,9.DOI:10.1016/j.ctmp.2025.200211
叶黄素对阿霉素所致雄性Wistar大鼠血管病变的预防机制
Preventive mechanisms of lutein on doxorubicin-induced vasculopathy in male Wistar rat
Jerome Ndudi Asiwe 1Oghenerukevwe Ematele 1JenniferEfeJaiyeoba-Ojigho 2Joseph Chimezie 3Princess Precious Aboribo 1Molly Fidelis 1Victory Rukevwe Obighele 1David Chidiebube Okoh 1Dorcas Oghenetejiri Meseikpe 1Marian Nwokoro1
作者信息
- 1. Department of Physiology,Faculty of Basic Medical Sciences,Delta State University,Abraka 330105,Delta State,Nigeria
- 2. Department of Anatomy,Faculty of Basic Medical Sciences,Delta State University,Abraka,330105,Delta State,Nigeria
- 3. Department of Physiology,Faculty of Basic Medical Sciences,Federal University of Technology,Akure,340106,Ondo State,Nigeria
- 折叠
摘要
Abstract
Background:Doxorubicin(DOX)treatment has been well-reported to hamper heart and arterial function,limiting its clinical application.Meanwhile lutein(LUT)has shown promising therapeutic prospects against many diseases,but no report has shown whether LUT can prevent DOX-associated vascular toxicity.
Objective:This study deciphers the mechanism of Lutein's preventive effect against DOX-induced vascular toxicity using rat model.
Methods:Twenty-four rats were grouped into the control(10 mL/kg distilled water with 1％dimethyl sulfoxide(DMSO),the DOX(15 mg/kg DOX in 1％DMSO),Lutein(LUT:40 mg/kg)and LUT+DOX groups and used for this study.Male experimental rats were pretreated with Lutein and distilled water in 1％DMSO for 28 days to establish a preventive experimental model while,DOX were given to DOX and LUT+DOX groups for 3 days starting from day 25.Vascular function,oxido-inflammatory,aortic apoptotic,autophagy and histopathology were assessed.
Results:lutein pretreatment mechanistically showed upregulation of nitric oxide(NO)bioavailability,reducing endothelin-1(ET-1),increased glutathione(GSH),superoxide dismutase(SOD),glutathione S-transferase(GST)as well as catalase while reducing inflammation(tumor necrosis factor-α and interleukin-6)and apoptosis(cas-pase 3)were significantly reduced through modulation of autophagic processes(Beclin-1/mammalian target of rapamycin(mTOR)).Also,histopathological changes were markedly alleviated.
Conclusion:This study suggests that lutein-mediated vaso-preventive effect against DOX-induced vascular toxicity by preserving the vascular functions.关键词
阿奇霉素/叶黄素/氧化-炎症/细胞凋亡/自噬/血管功能Key words
Doxorubicin/Lutein/Oxido-inflammatory/Apoptosis/Autophagy/Vascular function引用本文复制引用
Jerome Ndudi Asiwe,Oghenerukevwe Ematele,JenniferEfeJaiyeoba-Ojigho,Joseph Chimezie,Princess Precious Aboribo,Molly Fidelis,Victory Rukevwe Obighele,David Chidiebube Okoh,Dorcas Oghenetejiri Meseikpe,Marian Nwokoro..叶黄素对阿霉素所致雄性Wistar大鼠血管病变的预防机制[J].临床传统医学和药理学（英文）,2025,6(2):44-52,9.
