临床肝胆病杂志2025，Vol.41Issue(6)：1025-1029,5.DOI:10.12449/JCH250604
新技术在慢加急性肝衰竭全病程管理中的转化与落地
Translation and implementation of new technologies in the whole-course management of acute-on-chronic liver failure
何恺 1李海1
作者信息
- 1. 上海交通大学医学院附属仁济医院消化科,上海市消化疾病研究所,上海 200001
- 折叠
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a form of acute hepatic insufficiency that occurs in the context of a chronic liver disease,with a relatively high mortality rate.To improve the prognosis of ACLF patients,it is essential to early identify the patients with pre-ACLF and constantly optimize and innovate treatment regimens for the disease in the progressive stage.With more than 10 years of research,the Chinese CLIF consortium has developed an early warning model for ACLF and established a system for transferring high-risk patients to tertiary hospitals.At present,the real-world study has also confirmed the consistency between the early warning model and actual conditions in clinical practice,making contributions to the early screening,diagnosis,and treatment of ACLF.The treatment options for the progressive stage of ACLF are also expanding,from the development of innovative pharmaceuticals to the use of artificial liver support and stem cell therapy,and such treatment modalities have made significant achievements in clinical studies and are expected to be implemented in the near future.The development of a more efficient diagnostic system and novel treatment modalities has led to a significant improvement in the diagnosis and treatment of ACLF.关键词
慢加急性肝功能衰竭/早期诊断/治疗学/预后Key words
Acute-On-Chronic Liver Failure/Early Diagnosis/Therapeutics/Prognosis引用本文复制引用
何恺,李海..新技术在慢加急性肝衰竭全病程管理中的转化与落地[J].临床肝胆病杂志,2025,41(6):1025-1029,5.
