临床肝胆病杂志2025，Vol.41Issue(6)：1030-1036,7.DOI:10.12449/JCH250605
慢加急性肝衰竭预后评分模型和标志物研究进展
Research advances in prognostic score models and biomarkers for acute-on-chronic liver failure
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a complex clinical syndrome,and early identification and accurate prognostic evaluation are of great importance for patient treatment and management.In recent years,with in-depth research on the pathogenesis of ACLF,multiple prognostic biomarkers have been proposed and used in clinical practice.This article systematically reviews the research advances in prognostic biomarkers for ACLF from the aspects of clinical predictive models,immunological biomarkers,metabolic biomarkers,genetic and epigenetic biomarkers,microbiome-related biomarkers,and emerging technologies such as artificial intelligence and multi-omics,and it also discusses the value and application prospects of these biomarkers in the prognostic evaluation of ACLF and proposes future research directions,in order to provide a scientific and comprehensive reference for clinicians,guide individualized treatment and management of ACLF patients,and finally improve the clinical outcomes of patients.关键词
慢加急性肝功能衰竭/预后/生物标记/模型,统计学Key words
Acute-On-Chronic Liver Failure/Prognosis/Biomarkers/Models,Statistical引用本文复制引用
徐心怡,俞霞,屠慧烂,钱潇含,杨益大,施毓..慢加急性肝衰竭预后评分模型和标志物研究进展[J].临床肝胆病杂志,2025,41(6):1030-1036,7.基金项目
国家重点研发计划(2022YFC2304500) National Key Research and Development Program of China(2022YFC2304500) （2022YFC2304500）
