临床误诊误治2025，Vol.38Issue(13)：35-40,6.DOI:10.3969/j.issn.1002-3429.2025.13.008
外周血YAP、TGF-β1、CTGF水平与急性心肌梗死患者经皮冠状动脉介入术后心脏不良事件的关系
Relationship between Peripheral Blood YAP,TGF-β1 and CTGF Levels and Major Adverse Cardiac Events in Patients with Acute Myocardial Infarction after Percutaneous Coronary Intervention
摘要
Abstract
Objective To investigate the relationship between the levels of peripheral blood Yes-associated protein(YAP),transforming growth factor-β1(TGF-β1),connective tissue growth factor(CTGF)and major adverse cardiac events(MACE)after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 495 AMI patients treated with PCI from April 2022 to February 2023 were selected and followed up for 1 year.Ac-cording to the occurrence of MACE,the patients were divided into MACE group(n=84)and non-MACE group(n=411).The general data of MACE group and non-MACE group were compared,and the levels of YAP,TGF-β1,CTGF in patients with different severity of coronary artery disease were compared.The correlation between YAP,TGF-β1,CTGF levels and clinical indicators was analyzed.Binary logistic regression was used to analyze the risk factors of MACE in AMI patients.The receiv-er operating characteristic(ROC)curve was used to evaluate the predictive value of YAP,TGF-β1 and CTGF for MACE in AMI patients after PCI.Results Age,triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),severity of coronary artery disease and levels of YAP,TGF-β1 and CTGF in MACE group were significantly higher than those in non-MACE group(P<0.05).The levels of YAP,TGF-β1,and CTGF in patients with double-vessel disease and multi-vessel disease were significantly higher than those in patients with single-vessel disease(P<0.05).The levels of YAP and TGF-β1 in patients with multi-vessel disease were higher than those in patients with double-vessel disease(P<0.05).Correlation analysis showed that the levels of YAP,TGF-β1 and CTGF in AMI patients were positively correlated with age,TG,LDL-C and multi-vessel coro-nary artery disease(P<0.05).TG,multi-vessel coronary artery disease,YAP,TGF-β1 and CTGF were risk factors for MACE in AMI patients(P<0.05).ROC curve results showed that the area under the ROC curve of YAP,TGF-β1,CTGF alone and their combination for predicting MACE in AMI patients was 0.817,0.874,0.805,0.945,respectively,and the diagnostic value of combined detection was higher.Conclusions TG,multi-vessel coronary artery disease,YAP,TGF-β1 and CTGF are risk factors for MACE in AMI patients after PCI.Serum YAP,TGF-β1 and CTGF levels have higher predictive value for MACE in AMI patients after PCI.关键词
心肌梗死/经皮冠状动脉介入/心脏不良事件/Yes相关蛋白/转化生长因子-β1/结缔组织生长因子/危险因素Key words
Myocardial infarction/Percutaneous coronary intervention/Adverse cardiac events/Yes-associated pro-tein/Transforming growth factor-β1/Connective tissue growth factor/Risk factors分类
医药卫生引用本文复制引用
唐兴凯,崔晓娟,谯从超..外周血YAP、TGF-β1、CTGF水平与急性心肌梗死患者经皮冠状动脉介入术后心脏不良事件的关系[J].临床误诊误治,2025,38(13):35-40,6.基金项目
达州市科技计划项目(23ZDYF0024) （23ZDYF0024）
