临床与实验病理学杂志2025，Vol.41Issue(7)：892-896,903,6.DOI:10.13315/j.cnki.cjcep.2025.07.008
食管鳞状细胞癌中肿瘤周围退缩裂隙的出现与临床病理特征及预后的关系
Association between the presence of peritumoral retraction clefts and clinicopatho-logical features and prognosis in esophageal squamous cell carcinoma
朱宁 1李志文 2方媛 1李俐1
作者信息
- 1. 南京市第一医院/南京医科大学附属南京医院病理科,南京 210006
- 2. 南京鼓楼医院/南京医科大学鼓楼临床医学院病理科,南京 210008
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological significance of peritumoral retraction clefts(PRC)in esophageal squamous cell cancer(ESCC)and its correlation with prognosis.Methods 266 cases of esophageal squa-mous cell carcinoma were collected.Excluding the cases due to incomplete clinical data,cracks caused by the produc-tion process,and receiving preoperative adjuvant treatment,248 cases were finally counted.PRC was determined by the proportion of retraction clefts in the tumor volume of 10％.A retrospective analysis was conducted to explore the re-lationship between PRC and the clinicopathological features as well as prognosis of ESCC.Results Among 248 ESCC patients,114 cases had PRC,while 134 cases did not.Correlation analysis showed that PRC was closely related to his-tological grade,lymphatic invasion,lymph node metastasis,depth of tumor invasion and TNM stage of ESCC,and ES-CC patients with PRC were more likely to have lymphatic invasion and lymph node metastasis(P＜0.05).In patients without lymphatic invasion,the probability of nodal metastasis in patients with PRC was higher than those without PRC,and the difference was statistically significant(P＜0.001).Kaplan-Meier survival analysis showed that 5-year overall survival(P=0.001)and progression-free survival(P=0.002)in ESCC patients with PRC were significantly lower than those without PRC.Conclusion ESCC patients with PRC are more likely to have local invasiveness,lymphatic invasion and nodal metastasis,may predict the poor prognosis of ESCC patients.Patients with nodal metastasis are more common with PRC.关键词
食管肿瘤/鳞状细胞癌/肿瘤周围退缩裂隙/淋巴管侵犯/预后Key words
esophageal neoplasms/squamous cell carcinoma/peritumoral retraction clefts/lymphatic invasion/prog-nosis分类
医药卫生引用本文复制引用
朱宁,李志文,方媛,李俐..食管鳞状细胞癌中肿瘤周围退缩裂隙的出现与临床病理特征及预后的关系[J].临床与实验病理学杂志,2025,41(7):892-896,903,6.
