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吸入暴露下毒性相关有害结局路径研究进展

邢立国 张明明 陈烨

辽宁大学学报(自然科学版)2025,Vol.52Issue(2):136-144,9.
辽宁大学学报(自然科学版)2025,Vol.52Issue(2):136-144,9.

吸入暴露下毒性相关有害结局路径研究进展

Progress in Toxicity-Related Adverse Outcome Pathways Under Inhalation Exposure Research

邢立国 1张明明 1陈烨2

作者信息

  • 1. 辽宁大学药学院,辽宁沈阳 110036||沈阳沈化院测试技术有限公司,辽宁沈阳 110021
  • 2. 辽宁大学药学院,辽宁沈阳 110036
  • 折叠

摘要

Abstract

In recent years,the frameworks of adverse outcome pathways(AOPs)has entered a rapid growth phase.As an integrative biological knowledge framework,AOPs systematically elucidate inhalation toxicity mechanisms by constructing AOPs networks,providing a scientific basis for the development of alternative testing methods and risk assessment frameworks for novel chemicals.This paper briefly summarizes the research progress of inhalation toxicity-related AOPs,the application of AOPs frameworks in related fields,and the main challenges currently faced in AOPs development,aiming to provide theoretical support and references for further AOPs development and implementation.

关键词

有害结局路径(AOPs)/吸入暴露/定量AOPs/定性AOPs

Key words

adverse outcome pathways(AOPs)/inhalation exposure/quantitative adverse outcome pathways/qualitative adverse outcome pathways

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资源环境

引用本文复制引用

邢立国,张明明,陈烨..吸入暴露下毒性相关有害结局路径研究进展[J].辽宁大学学报(自然科学版),2025,52(2):136-144,9.

辽宁大学学报(自然科学版)

1000-5846

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