老年医学与保健2025，Vol.31Issue(3)：642-646,652,6.
老年代谢相关脂肪性肝病及其纤维化程度与冠心病的相关性分析
Study on relationship between metabolic-associated fatty liver disease and its fibrosis degree with coronary artery disease in the elderly
摘要
Abstract
Objective To analyze the clinical characteristics of metabolic associated fatty liver disease(MAFLD)com-plicated with coronary artery disease(CAD)in elderly patients.Methods A total of 1 059 patients who underwent coronary angiography(CAG)and hepatic ultrasonography in Huadong Hospital between December 2022 and July 2024 were enrolled.Differences between MAFLD group and non-MAFLD group were compared,and the correlation between MAFLD(including its fibrosis severity)and CAD was analyzed.T-tests or rank sum tests were used to compare measurement data,and Chi-squared test was used to compare categorical data between the two groups.Results There were significant differences in the prevalence and severity of CAD between the MAFLD group and the non-MAFLD group.High-density lipoprotein(HDL),male sex,smoking,platelet count,glycated hemoglobin(HbA1c),aspartate aminotransferase(AST),and fibrinogen were identified as major influencing factors for CAD.The fibrosis degree score of MAFLD was significantly positively correlated with CAD.Af-ter adjusting for covariates,this conclusion still held(all P＜0.05).Conclusion The prevalence and severity of MAFLD in the elderly patients with CAD are relatively high,and the risk of CAD may increase with the progression of liver fibrosis.关键词
老年/代谢相关脂肪性肝病/冠状动脉粥样硬化性心脏病/经皮冠状动脉介入术/危险因素Key words
elderly/metabolic-associated fatty liver disease/coronary artery disease/percutaneous coronary interven-tion/risk factors引用本文复制引用
施佳恒,周灿灿,王姣锋,马一鸣,叶丹,甄思雨,牛怡然,胡晓娜,保志军..老年代谢相关脂肪性肝病及其纤维化程度与冠心病的相关性分析[J].老年医学与保健,2025,31(3):642-646,652,6.基金项目
上海市2024年度"科技创新动计划"医学创新研究专项(24Y12801100) （24Y12801100）
中国青年医学创新研究科研课题(P24062087783) （P24062087783）
东方英才青年项目 （）
