老年医学与保健2025，Vol.31Issue(3)：647-652,6.
三酰甘油葡萄糖指数与老年非介入治疗非ST段抬高型心肌梗死患者预后的关系研究
Study on relationship between triglyceride-glucose index and prognosis of elderly patients with non-ST-segment elevation myo-cardial infarction undergoing non-interventional therapy
摘要
Abstract
Objective To investigate the predictive value of the triglyceride-glucose(TyG)index for the prognosis of elderly patients with non-ST-segment elevation myocardial infarction(NSTEMI)undergoing non-interventional therapy.Methods The clinical data from 80 elderly patients diagnosed with NSTEMI and undergoing non-interventional therapy in Car-diac Care Unit of Huadong Hospital,Fudan University,between July 2018 and June 2022 were retrospectively analyzed.They were divided into low-TyG group(n=40)and high-TyG group(n=40)based on the median TyG index value.The general characteristics were compared between the two groups.All-cause mortality after discharge was followed up.Results The 80 elderly NSTEMI patients had an age range of 60 to 97 years(mean 80.8±9.4 years),with a median TyG index of 8.70.Compared with the low-TyG group,the high-TyG group had significantly younger age,higher body mass index(BMI),lower proportion of alcohol consumption history,higher proportion of diabetes mellitus,and higher levels of total cholesterol,triglyc-erides,and fasting blood glucose(all P＜0.05).During follow-up,20 patients died in the high-TyG group and 13 ones died in the low-TyG group.Kaplan-Meier survival analysis showed that the low-TyG group had a significantly better prognosis than the high-TyG group(P=0.046).Multivariate Cox proportional hazards regression analysis identified the increased TyG index(HR=2.442,95％CI:1.449-4.117),peak troponin T(HR=1.274,95％CI:1.037-1.565),B-type natriuretic peptide(BNP)(HR=1.001,95％CI:1.000-1.001),and advanced age(HR=1.050,95％CI:1.004-1.099)as independent prognostic factors affecting sur-vival in elderly NSTEMI patients undergoing non-interventional therapy.Conclusion Elderly NSTEMI patients undergoing non-interventional therapy with a lower TyG index may have a lower risk of mortality than those with a higher TyG index.关键词
老年/三酰甘油葡萄糖指数/胰岛素抵抗/非ST段抬高型心肌梗死/预后Key words
elderly/triglyceride-glucose index/insulin resistance/non-ST-segment elevation myocardial infarction/prog-nosis引用本文复制引用
李明轩,潘涵沁,李思奇,史凯蕾,张冬梅..三酰甘油葡萄糖指数与老年非介入治疗非ST段抬高型心肌梗死患者预后的关系研究[J].老年医学与保健,2025,31(3):647-652,6.基金项目
上海市自然科学基金(22ZR1422000) （22ZR1422000）
申康促进临床专科能力提升项目(SHDC22023302) （SHDC22023302）
