辽宁中医杂志2025，Vol.52Issue(7)：5-8,后插2,5.DOI:10.13192/j.issn.1000-1719.2025.07.002
基于SIP合胞体探讨疏肝健脾法促进功能性消化不良胃肠动力的作用机制
Exploring Mechanism of Promoting Gastrointestinal Motility of Functional Dyspepsia by Soothing Liver and Invigorating Spleen Method Based on SIP Syncytial
摘要
Abstract
Functional dyspepsia(FD)is associated with the imbalance of ICC-ANO1/PDGFRα+cell-SK3 pathway in SIP syncytium which is the key to maintain normal gastrointestinal motility.Disorder of normal physiological function of liver and spleen is the basic pathogenesis of FD.Soothing liver and invigorating spleen method is an essential treatment concept for FD.Ad-ditionally,the previous study of the research group has found that the improvement of gastrointestinal motility in FD by soothing liver and invigorating spleen method is related to the regulation of gastrointestinal myoelectrical activity and the release of brain-intestinal peptides.However,it is currently unclear whether the intervention in FD can be achieved by regulating SIP syncytial.Therefore,this research has proposed the scientific hypothesis that soothing liver and invigorating spleen method promotes the gas-trointestinal motility of FD by regulating SIP syncytium through the ICC-ANO1/PDGFRα+cell-SK3 pathway.Based on the ICC-ANO1/PDGFRα+cell-SK3 pathway and used cytology,molecular biology and whole-cell patch-clamp methods,the present project will investigate the effect of serum containing traditional Chinese medicine on ICC/PDGFRα+cells by soothing liver and invigorating spleen method.A rat model of FD gastrointestinal motility disorder was established to clarify the intervention effect of soothing liver and invigorating spleen method.The molecular biology and electrophysiological techniques were used to ver-ify the improvement of FD gastrointestinal motility disorder by regulating SIP syncytium and the related mechanisms.关键词
功能性消化不良/胃肠动力/SIP合胞体/疏肝健脾/作用机制Key words
functional dyspepsia/gastrointestinal motility/SIP syncytium/soothing liver and invigorating spleen/mechanism of action分类
医药卫生引用本文复制引用
毛兰芳,刘俊宏,张晶,牛媛媛,杜晓娟,李正菊,汪龙德..基于SIP合胞体探讨疏肝健脾法促进功能性消化不良胃肠动力的作用机制[J].辽宁中医杂志,2025,52(7):5-8,后插2,5.基金项目
国家自然科学基金项目(82160883,82460908) （82160883,82460908）
2020年度甘肃中医药大学科学研究与创新基金重点项目(30140301) （30140301）
2023年甘肃省教育科技创新项目(2023B-108) （2023B-108）
甘肃省中医药管理局重点项目(GZKZ-2022-5) （GZKZ-2022-5）
