南京中医药大学学报2025，Vol.41Issue(7)：856-868,13.DOI:10.14148/j.issn.1672-0482.2025.0856
类器官技术在中医药领域的应用全景:从基础机制到临床实践的机遇与挑战
Panorama of Organoid Technologies in Chinese Medicine:Opportunities and Challenges from Basic Mechanisms to Clinical Practice
摘要
Abstract
By systematically reviewing the development history of organoid technology and its application examples in Chinese med-icine,this paper summarizes the specific applications of organoids in the mechanism and translation of Chinese medicine,pathological mechanisms,diagnostic techniques,and therapeutic strategies,and evaluate their advantages and limitations through literature analysis.Organoid technology provides an in vitro model that highly simulates the function of human organs for TCM research,and can simulate the multi-target and multi-pathway mechanism of action of TCM,which significantly improves the scientificity and precision of TCM in the analysis of disease mechanisms,drug screening and personalized treatment.However,it still faces challenges in stand-ardization,ethical regulation,and clinical translation.The combination of organoid technology and TCM has a broad prospect,and it is necessary to further optimize the model construction,resolve ethical issues,and promote its wide application in TCM research and clin-ical practice through technological innovation,interdisciplinary cooperation,and international regulatory coordination in the future.关键词
类器官/中医药/中医药机制/诊断技术/治疗策略/体外模型Key words
organoid/Chinese medicine/Chinese medicine mechanism/diagnostic technology/therapeutic strategy/in vitro model分类
医药卫生引用本文复制引用
黄蕊,苏联麟,季德,殷放宙,陆兔林,邵怡,李林..类器官技术在中医药领域的应用全景:从基础机制到临床实践的机遇与挑战[J].南京中医药大学学报,2025,41(7):856-868,13.基金项目
国家重点研发计划(2023YFC3504200) （2023YFC3504200）
中药炮制技术传承创新项目(GZY-KJS-2022-050) （GZY-KJS-2022-050）
