中国海洋大学学报（自然科学版）2025，Vol.55Issue(8)：111-115,5.DOI:10.16441/j.cnki.hdxb.20240190
高碳糖中2-羟基亚乙基导向基脱除新方法
A Novel Method for the Removal of 2-hydroxyethylene Directing Group from Higher-Carbon Sugars
摘要
Abstract
2-hydroxyethylene is used as a directing group for the synthesis of higher-carbon sugars,but there are few methods for the removal of this directing group.In order to efficiently remove this group under mild conditions,m-CPBA/TEMPO/TBAB reaction system was used to convert 2-hydroxyethyl-ene to hemiacetal formate,which was selectively hydrolyzed by Et3N/MeOH to obtain hemiacetal inter-mediates.The hemiacetal underwent hydrolysis to result in the final removal of 2-hydroxyethyl after simple work-up.The reaction proceeded under mild reaction conditions and enjoyed a wide range of sub-strates,as exemplified by the removal of 2-hydroxyethyl from eight high-carbohydrate sugars with a yield of 49%～63%.The present method greatly improves the synthesis efficiency of higher-carbon sugars.关键词
2-羟基亚乙基/半缩醛/高碳糖Key words
2-hydroxyethylene/hemiacetal/higher-carbon sugars分类
医药卫生引用本文复制引用
刘利华,李东伟,王鹏,宋妮,李明..高碳糖中2-羟基亚乙基导向基脱除新方法[J].中国海洋大学学报（自然科学版）,2025,55(8):111-115,5.基金项目
国家自然科学基金项目(22377114,21977088)资助 Supported by the National Natural Science Foundation of China(22377114,21977088) （22377114,21977088）
