肿瘤预防与治疗2025，Vol.38Issue(7)：563-571,9.DOI:10.3969/j.issn.1674-0904.2025.07.002
血小板在肿瘤诊断和靶向治疗中的研究进展及挑战
Platelets in Tumor Diagnosis and Treatment:Research Progress and Challenges
摘要
Abstract
Platelets,in addition to their critical roles in hemostasis and wound healing,have been shown to participate in several key stages of tumorigenesis,including tumor growth,tumor cell extravasation,invasion,and distant metastasis.Upon activation,platelets secrete a variety of molecules,such as growth factors,lipids,and extracellular vesicles,which coordinate local and distant crosstalk between the tumor and host.This enhances the malignancy of tumor cells and pro-motes tumor invasion and colonization of distant organs.Moreover,platelets can capture proteins and transcripts from the peripheral circulation,either directly or through induction,resulting in specific proteomic and transcriptomic expression patterns in platelets from cancer patients.These platelet expression profiles serve as valuable biomarkers for early cancer detection and disease monitoring.Given the critical role of platelets in tumor progression and their ability to carry tumor-as-sociated molecular cargo,platelet-based molecular diagnostics and antiplatelet therapies present promising strategies for im-proving cancer diagnosis and treatment outcomes.This review provides a detailed examination of the dynamic roles of plate-lets in tumor development and progression,explores their potential applications in cancer diagnosis,prognosis,and monito-ring treatment responses,and discusses the challenges in developing precise antiplatelet strategies for safe and effective clinical cancer therapy.关键词
血小板/肿瘤诊断/抗血小板治疗/治疗监测Key words
Platelets/Tumor diagnosis/Antiplatelet therapy/Treatment monitoring分类
医药卫生引用本文复制引用
张开炯,凌晗,王东生..血小板在肿瘤诊断和靶向治疗中的研究进展及挑战[J].肿瘤预防与治疗,2025,38(7):563-571,9.基金项目
国家自然科学基金青年基金项目(编号:82302907) （编号:82302907）
四川省自然科学基金项目(编号:2023NSFSC1898、2024NSFSC1880、2025ZNSFSC0560) （编号:2023NSFSC1898、2024NSFSC1880、2025ZNSFSC0560）
四川省干部保健科研项目(编号:川干研2022-802) （编号:川干研2022-802）
成都市科技局项目(编号:2024-YF05-01125-SN) This study was supported by National Natural Science Foundation of China(No.82302907),and by grants from Science and Technology Department of Sichuan Province(No.2023NSFSC1898,No.2024NSFSC1880,No.2025ZNSFSC0560),Health Commission of Sichuan Province(No.Chuan Gan Yan 2022-802),and Science and Technology Bureau of Chengdu(No.2024-YF05-01125-SN). （编号:2024-YF05-01125-SN）
