肿瘤预防与治疗2025，Vol.38Issue(7)：572-586,15.DOI:10.3969/j.issn.1674-0904.2025.07.003
高强度间歇性训练对乳腺癌患者峰值摄氧量、生活质量、身体成分及癌因性疲乏影响的Meta分析
Effect of High-Intensity Interval Training on Peak Oxygen Uptake,Quali-ty of Life,Body Composition and Cancer-Related Fatigue in Patients with Breast Cancer:A Meta-Analysis
摘要
Abstract
Objective:To comprehensively and quantita-tively evaluate the efficacy of high-intensity interval training(HIIT)in the rehabilitation of patients with breast cancer through a Meta-analysis,and to further validate the feasibility of HIIT application in cancer populations.Methods:Randomized controlled trials(RCTs)on the intervention effects of HI-IT in patients with breast cancer were retrieved from databases including CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,The Cochrane Library,CINAHL Embase,Scopus,and Medline up to June 2024.After literature screening,infor-mation extraction,and quality assessment by two researchers,Meta-analysis was conducted using RevMan5.3 software.This protocol has been registered on the PROSPERO platform(registration number:CRD42024561661).Results:A total of 18 studies were included.Meta-analysis results indicate that HIIT significantly enhances peak oxygen uptake(SMD=0.33,95％Cl:0.18～0.49,Z=4.15,P＜0.001)and quality of life(SMD=0.46,95％CI:0.13～0.79,Z=2.77,P=0.006)in patients with breast cancer,alleviates cancer-related fatigue(SMD=-0.36,95％CI:-0.58～-0.14,Z=3.15,P=0.002),and improves body composition,particularly in terms of body weight(SMD=-0.23,95％CI:-0.39～-0.06,Z=2.64,P=0.008),fat mass(SMD=-0.29,95％CI:-0.53～-0.04,Z=2.31,P=0.020),and lean body mass(SMD=0.37,95％CI:0.09～0.66,Z=2.54,P=0.010).However,HIIT does not significantly affect body fat percentage(SMD=-0.09,95％CI:-0.46～0.29,Z=0.46,P=0.650).Conclusion:HIIT effectively enhances peak oxygen up-take,mitigates cancer-related fatigue,and improves the quality of life in patients with breast cancer.Additionally,it amelio-rates body weight,fat mass and lean body mass,but does not significantly reduce body fat percentage.关键词
高强度间歇性训练/峰值摄氧量/生活质量/身体成分/癌因性疲乏/乳腺癌/Meta分析Key words
High-intensity interval-training/Peak oxygen uptake/Quality of life/Body composition/Cancer-related fatigue/Breast cancer/Meta-analysis分类
医药卫生引用本文复制引用
刘文玲,徐百超,张翔,赵晓婷,张灵,王诗源,刘伟,高星..高强度间歇性训练对乳腺癌患者峰值摄氧量、生活质量、身体成分及癌因性疲乏影响的Meta分析[J].肿瘤预防与治疗,2025,38(7):572-586,15.基金项目
国家自然科学基金(编号:81960420) （编号:81960420）
海南省自然科学基金(编号:825ms094) （编号:825ms094）
海南省重点研发项目(编号:ZDYF2022SFSHFZ306) This study was supported by National Natural Science Foundation of China(No.81960420)and Natural Science Foundation of Hainan Province(No.825ms094),and by grants from Science and Technology of Hainan Province(No.ZDYF2022SFSHFZ306). （编号:ZDYF2022SFSHFZ306）
