肿瘤预防与治疗2025，Vol.38Issue(7)：593-597,5.DOI:10.3969/j.issn.1674-0904.2025.07.005
羊膜腔穿刺术对乙型肝炎病毒母婴传播的影响:肝癌一级预防策略的思考
Impact of Amniocentesis on Mother-to-Child Transmission of Hepatitis B Virus:Reflections on Primary Prevention Strategies for Liver Cancer
杨川梅 1汪亚莉 1刘叶1
作者信息
- 1. 641400 成都,简阳市妇幼保健院/简阳市妇女儿童医院产科
- 折叠
摘要
Abstract
Objective:To analyze the impact of amniocentesis on the risk of mother-to-child transmission of hepatitis B virus(HBV)in hepatitis B surface antigen(HBsAg)-positive mothers,and to provide evidence for primary prevention strate-gies of liver cancer.Methods:A retrospective analysis included HBsAg positive pregnant women and their newborns who re-ceived regular antenatal checkups and hospitalized delivery at the Jianyang Maternal and Child Health Hospital from January 2022 to December 2024 as a target subjects.A total of 66 pregnant women and their newborns who underwent amniocentesis during pregnancy were selected as the study group.According to a matched case-control study design,delivery time(±3 days)and fetal gender(of the same gender)were used as matching factors.Pregnant women and their newborns who did not undergo amniocentesis were included as the control group with a ratio of 1∶2.Clinical data related to mother-to-child transmission of HBV were collected,and the infection rates of the two groups were compared.Logistic regression model was used to analyze whether amniocentesis increased the risk of HBV transmission from mother to child.Results:Three in-fants in the study group were tested positive for HBsAg at 7 months of age,with a mother-to-child transmission rate of 4.55％(3/66).The control group were all negative for serum HBsAg(0/132)at 7 months of age,and the mother-to-child trans-mission rate of HBV in the study group was significantly higher than that in the control group(x2=6.092,P=0.014).Uni-variate analysis showed that the incidence of HBV infection in pregnant women positive for hepatitis B e antigen(HBeAg)was significantly higher than that in pregnant women negative for HBeAg,and the difference was statistically significant(17.65％vs 0.00％,P=0.003);The incidence of HBV infection in pregnant women with HBV-DNA virus quantification≥ 107 IU/mL was significantly higher than those with virus quantification＜107 IU/mL,and the difference was statistically significant(27.27％vs 0.00％,P＜0.001).Multivariate logistic regression analysis showed that amniocentesis increased the risk of mother-to-child vertical transmission in HBV infected pregnant women,and the risk of infection was 6.153 times higher than that in HBV infected pregnant women without amniocentesis(95％CI:1.481～23.454).Conclusion:Amniocentesis among HBeAg positive pregnant women may increase the risk of vertical transmission from mother to child,but further exploration is needed to guide clinical doctors in improving prenatal diagnosis rates and preventing the occurrence of HBV-HCC chronic transformation while controlling intrauterine infection.关键词
羊膜腔穿刺术/乙型肝炎病毒/母婴传播/肝癌/一级预防Key words
Amniocentesis/Hepatitis B virus/Mother-to-child transmission/Liver cancer/Primary prevention分类
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杨川梅,汪亚莉,刘叶..羊膜腔穿刺术对乙型肝炎病毒母婴传播的影响:肝癌一级预防策略的思考[J].肿瘤预防与治疗,2025,38(7):593-597,5.
