摘要
Abstract
Objective:To explore the risk factors for female patients with condyloma acuminatum(CA)complicated with genital malignant tumors,thus provide reference for early identification of high-risk populations and reducing the incidence of malignant tumors.Methods:Fifty-five cases of female CA patients complicated with genital malignant tumors who were ad-mitted to the Traditional Chinese Medicine Skin Clinic of our hospital from January 2020 to June 2024 were enrolled as the case group,and age(±3 years)and visit time(±7 days)were used as paired factors to collect 110 cases of female non ma-lignant tumor CA patients in a 1︰2 ratio as the control group.Demographic information,sexual behavior characteristics,lif-estyle,and disease characteristics of the two groups of patients were collected,and univariate analysis and multivariate un-conditional Logistic regression model were used to explore the relevant risk factors of female CA patients complicated with genital malignant tumors.Results:Univariate analysis showed that fertility history,family history of gynecological tumors,age of first sexual intercourse,number of sexual partners,course of CA,human papillomavirus(HPV)subtypes were associated with concomitant genital malignancies(all P＜0.05).Unconditional multivariate logistic regression analysis showed that a family history of gynecological tumors(OR=32.992,P=0.009),younger age of first sexual intercourse(OR=0.905,P=0.044),more sexual partners(OR=1.976,P=0.048),longer duration of CA(OR=27.122,P＜0.001),and HR-HPV infection(OR=4.776,P=0.002)were independent risk factors for female CA patients with concurrent genital malignancy.Conclusion:Family history of gynecological malignant tumors,adverse sexual behaviors(premature sexual be-havior,multiple sexual partners),and disease factors(long course,HR-HPV infection)are independent risk factors for fe-male CA patients to develop genital malignant tumors.For CA patients with the above risk factors,individualized evaluation and secondary prevention should be carried out to reduce the incidence of malignant tumors.关键词
女性/尖锐湿疣/生殖器恶性肿瘤/危险因素/Logistic回归模型Key words
Women/Condyloma acuminate/Genital malignant tumors/Risk factors/Logistic regression model分类
医药卫生
