肿瘤预防与治疗2025，Vol.38Issue(7)：626-631,6.DOI:10.3969/j.issn.1674-0904.2025.07.010
树突状细胞在乳腺癌免疫治疗中的研究进展
Research Progress of Dendritic Cells in Immunotherapy for Breast Cancer
摘要
Abstract
Dendritic cells(DC)are the most powerful antigen-presenting cells that play important roles in immunotherapy of breast cancer.However,the function of tumor infiltrating DC are often inhibited and cannot produce anti-tumor activity in the tumor microenvironment.Therefore,activating and restoring the normal function of DC pivotal to enhance the efficacy of immunotherapy in breast cancer.Drugs,cancer vaccines,and vaccine combined with chemotherapy,radiotherapy,targeted therapy and immunotherapy which used to enhance DC antigen presentation function have shown promising effect in clinical.This article summarized the main function of DC in tumor immunity and its research progress in breast cancer immunothera-py,providing new insights for effectively improving the therapeutic efficacy of breast cancer.关键词
树突状细胞/乳腺癌/免疫治疗/肿瘤疫苗/联合治疗Key words
Dendritic cells/Breast cancer/Immunotherapy/Cancer vaccine/Combination therapy分类
医药卫生引用本文复制引用
高宇,张媛..树突状细胞在乳腺癌免疫治疗中的研究进展[J].肿瘤预防与治疗,2025,38(7):626-631,6.基金项目
国家自然科学基金(编号:82304532) （编号:82304532）
广东省基础与应用基础研究基金(编号:2024A1515220102) This study was supported by National Natural Science Foundation of China(No.82304532),and by grants from Department of Science and Technology of Guangdong Province(No.2024A1515220102). （编号:2024A1515220102）
