山东中医杂志2025，Vol.44Issue(7)：734-739,748,7.DOI:10.16295/j.cnki.0257-358x.2025.07.003
肝藏象理论研究实践——情志病证PMS/PMDD研究
Research and Practice on Theory of Visceral Manifestations of Liver
摘要
Abstract
Visceral manifestations theory of liver(LVMT)is one of the important contents of tradirional Chinese medicine(TCM)visceral manifestations theory.Deepening its scientific connotation and promoting its inheritance and innovation to guide clinical practice have been important propositions in the basic research of TCM.This article systematically reviews the development history and basic consensus of the research on LVMT,emphasizing that the physiological characteristic of"liver governing and regulating"is closely related to emotional disorders and gynecological diseases.However,its modern research still faces challenges such as theoretical and clinical disconnection and insufficient integration of traditional Chinese and Western medicine,which urgently needs key breakthrough points.Taking premenstrual syndrome(PMS)/premenstrual dysphoric disorder(PMDD)as the entry point,this paper reveals the deep association between liver dysfunction(either excessive or insufficient)and the neuroendocrine mechanism in Western medicine.It is proposed that the states of liver dysfunction,imbalance of Chong and Ren meridians,and disharmony of nutrient-defense in patients with PMDD are consistent with the functional abnormalities of the gamma-aminobutyric acid(GABA)ergic system,the negative feedback disorder of the hypothalamus-pituitary-adrenal(HPA)axis,and the immune disorder mechanism.From the perspective of constitution theory,the influence of genetic factors and environmental factors on the susceptibility to PMS/PMDD has been emphasized.Future research should be based on the holistic view of TCM,construct a four-dimensional framework of"phenomenon-data-mechanism-theory",integrate systems biology and artificial intelligence technologies,deepen the analysis of the microscopic regulatory network of the LVMT,promote complementary advantages of traditional Chinese and Western medicine,and facilitate the leap of TCM from empirical medicine to precision medicine.关键词
肝藏象/肝主疏泄/情志病证/经前期综合征/经前烦躁障碍症/神经内分泌Key words
visceral manifestations of liver/liver governing and regulating/emotional diseases/premenstrual syndrome/premenstrual dysphoric disorder/neuroendocrine mechanism分类
医药卫生引用本文复制引用
郭英慧,宋春红,高明周..肝藏象理论研究实践——情志病证PMS/PMDD研究[J].山东中医杂志,2025,44(7):734-739,748,7.基金项目
国家自然科学基金面上项目(编号:82074293) （编号:82074293）
山东省高等学校"青创团队计划"-中医情志病与脑稳态调控创新团队项目(编号:2023KJ191) （编号:2023KJ191）
山东省研究生教育教学改革研究项目(编号:SDYJSJGC2024063) （编号:SDYJSJGC2024063）
山东省研究生精品和优质专业学位教学案例库项目(编号:SDYAL2024147) （编号:SDYAL2024147）
山东中医药大学科学研究基金项目(编号:KYZK2024M08) （编号:KYZK2024M08）
