山东中医杂志2025，Vol.44Issue(7)：767-773,7.DOI:10.16295/j.cnki.0257-358x.2025.07.009
温阳祛瘀方联合针灸治疗腰椎间盘突出症根性坐骨神经痛临床研究
Clinical Study on Wenyang Quyu Formula(温阳祛瘀方)Combined with Acupuncture and Moxibustion in Treatment of Root Sciatica Caused by Lumbar Intervertebral Disc Protrusion
摘要
Abstract
Objective:To observe the effects of the Wenyang Quyu Formula(温阳祛瘀方)combined with acupuncture and moxibustion on pain,surface electromyography signals and serological indicators in patients with root sciatica caused by lumbar intervertebral disc protrusion.Methods:A total of 102 patients with lumbar intervertebral disc protrusion and root sciatica treated in Lu'an People's Hospital were selected and divided into the acupuncture group and the combined acupuncture and medication group by using the random number table method,with 51 cases in each group.Both groups were given western medicine symptomatic treatment simultaneously.The acupuncture group was given acupuncture treatment on this basis,and the combined acupuncture and medication group was treated with the Wenyang Quyu Formula on the basis of the treatment of the acupuncture group.The lumbar spine ranges of motion,Oswestry Disability Index(ODI)score,RoRoland Morris Disability Questionnaire(RMDQ)score,and 6-point Behavior Scale(BRS-6)score of the two groups of patients before and after treatment were compared.The average electromyography values and median frequency values of the multifidus muscle and erector spinae muscle electromyography signals in the lumbar region before and after treatment were compared between the two groups of patients.The levels of monocyte chemoattractant protein-1(MCP-1),thrombus B2(TXB2),α 1-acid glycoprotein(α1-AGP),and helper T cell type 1/helper T cell type 2(Th1/Th2),M-type brain natriuretic peptide(M-ENK),5-hydroxytryptamine(5-HT),neurokinin 1,substance P,of the two groups of patients before and after treatment were detected.The clinical efficacy of the two groups of patients was evaluated.Results:After treatment,the range of motion of the lumbar vertebrae in both groups increased compared with that before treatment,and the range of motion of the lumbar vertebrae in the combined acupuncture and medication group was higher than that in the acupuncture group(P＜0.05).After treatment,the ODI scores,RMDQ scores and BRS-6 scores of both groups were lower than those before treatment,and the combined acupuncture and medication group was lower than the acupuncture group(P＜0.05).After treatment,the average electromyography values and median frequency values of the multifidus and erector spinae muscle electromyography signals in both groups increased compared with those before treatment,and the combined acupuncture and medication group was higher than the acupuncture group(P＜0.05).After treatment,the levels of MCP-1,TXB2,α1-AGP,and Th1/Th2 in both groups decreased compared with those before treatment,and the levels in the combined acupuncture and medication group were lower than those in the acupuncture group(P＜0.05).The M-ENK in both groups increased compared with that before treatment,and the combined acupuncture and medication group was higher than the acupuncture group(P＜0.05).The levels of 5-HT,neurokinin 1 and substance P in both groups were lower than those before treatment,and the levels in the combined acupuncture and medication group were lower than those in the acupuncture group(P＜0.05).The total effective rate of patients in the combined acupuncture and medication group was 96.08％,which was better than that of the acupuncture group(80.39％).Comparison of the clinical efficacy between the two groups showed a statistically significant difference(P＜0.05).Conclusions:The combination of Wenyang Quyu Formula and acupuncture and moxibustion can regulate the Th1/Th2 levels in peripheral blood,reduce inflammatory responses,improve the surface electromyography signals and pain medium indicators of patients in the treatment of patients with root sciatica caused by lumbar intervertebral disc protrusion,enhance the range of motion of the lumbar vertebrae,clinical efficacy,analgesic effect and quality of life.关键词
温阳祛瘀方/针灸/腰椎间盘突出症/根性坐骨神经痛/Th1/Th2/表面肌电信号/疼痛介质Key words
Wenyang Quyu Formula/acupuncture and moxibustion/lumbar intervertebral disc protrusion/root sciatica/Th1/Th2/surface electromyography signal/pain mediator分类
医药卫生引用本文复制引用
徐倩,武俊,姚延敬..温阳祛瘀方联合针灸治疗腰椎间盘突出症根性坐骨神经痛临床研究[J].山东中医杂志,2025,44(7):767-773,7.基金项目
安徽省高等学校自然科学研究项目(编号:KJ2020A0577) （编号:KJ2020A0577）
