山东中医杂志2025，Vol.44Issue(7)：774-780,7.DOI:10.16295/j.cnki.0257-358x.2025.07.010
益气冠脉通心方联合八段锦治疗冠心病慢性心力衰竭临床研究
Clinical Study on Yiqi Guanmai Tongxin Formula(益气冠脉通心方)Combined with Baduanjin on Chronic Heart Failure due to Coronary Heart Disease
摘要
Abstract
Objective:To observe the clinical efficacy of Yiqi Guanmai Tongxin Formula(益气冠脉通心方)combined with Baduanjin in the treatment of patients with chronic heart failure due to coronary heart disease,as well as its effects on myocardial fibrosis and inflammatory injury,etc.Methods:A total of 100 patients with chronic heart failure due to coronary heart disease were selected and divided into control group and observation group according to the random number table method,with 50 cases in each group.Both groups were given standardized western medical treatment simultaneously.The control group was treated with the Yiqi Guanmai Tongxin Formula,while the observation group was treated with the Yiqi Guanmai Tongxin Formula combined with Baduanjin.The changes of traditional Chinese medicine(TCM)syndrome scores and ventricular rate-related indicators before and after treatment in the two groups were observed.The indicators related to inflammatory response[Interleukin-17(IL-17A),Lipoprotein phospholipase A2(Lp-PLA2)]and vascular regeneration[vascular endo-thelial growth factor(VEGF),Hypoxia-Inducible factor 1α(HIF-1α)],and indicators related to myocardial fibrosis injury[C1q-tumor necrosis factor-related protein 3(CTRP3),hyaluronic acid(HA),type Ⅲ procollagen(PC Ⅲ)]before and after treatment were compared between the two groups.The left ventricular ejection fraction(LVEF),myocardial energy expenditure(MEE),and left ventricular myocardial mass index(LVMI)of the two groups before and after treatment were detected.And the clinical efficacy of the two groups was evaluated.Results:After treatment,the scores of each TCM syndrome in both groups were lower than those before the treatment,and the scores in the observation group were lower than those in the control group(P＜0.05).After treatment,the minimum,maximum and average ventricular rates in both groups were lower than those before treatment,and the rates in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of IL-17A,Lp-PLA2,HA and PC Ⅲ in both groups decreased compared with those before treatment,and the levels in the observation group were lower than those in the control group(P＜0.05).The levels of HIF-1α,VEGF and CTRP3 all increased compared with those before treatment,and those in the observation group were higher than those in the control group(P＜0.05).After treatment,the LVEF in both groups increased compared with that before treatment(P＜0.05),and the LVEF in the observation group was higher than that in the control group(P＜0.05).The MEE and LVMI in both groups were lower than those before treatment(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).The total effective rate of treatment in the control group was 80.00％,which was lower than 96.00％in the observation group.Comparison of the clinical efficacy between the two groups showed a statistically significant difference(P＜0.05).Conclusions:Yiqi Guanmai Tongxin Formula combined with Baduanjin can reduce inflammatory injury,myocardial fibrosis and vascular regeneration,improve atrial fibrillation,regulate ventricular remodeling and myocardial energy metabolism,alleviate the condition and enhance clinical efficacy in the treatment of patients with chronic heart failure due to coronary heart disease.关键词
益气冠脉通心方/八段锦/冠心病/慢性心力衰竭/炎性损伤/心肌纤维化/血管再生/心房颤动Key words
Yiqi Guanmai Tongxin Formula/Baduanjin/coronary heart disease/chronic heart failure/inflammatory injury/myocardial fibrosis/vascular regeneration/atrial fibrillation分类
医药卫生引用本文复制引用
韩子龙,王越,宋磊,罗玉环..益气冠脉通心方联合八段锦治疗冠心病慢性心力衰竭临床研究[J].山东中医杂志,2025,44(7):774-780,7.基金项目
国家中医药管理局全国优秀人才研修项目(编号:2020ZYLCY006-062) （编号:2020ZYLCY006-062）
