山东农业科学2025，Vol.57Issue(6)：121-132,12.DOI:10.14083/j.issn.1001-4942.2025.06.014
pH响应型GO-L-Ser-KM纳米农药制备及其对烟草赤星病的防控
Preparation of pH-Responsive GO-L-Ser-KM Nano-pesticide and Its Control Effect on Tobacco Brown Spot
摘要
Abstract
Stimuli-responsive controlled-release pesticide delivery systems(PDS)based on nanocarriers have emerged as novel and promising approaches for efficient utilization of pesticides.In this study,L-serine(L-Ser)modified graphene oxide(GO)was ingeniously utilized as the delivery vehicle for kresoxim-methyl(KM),enabling the construction of a highly efficient and pH-responsive controlled-release nano-pesticide sys-tem,namely GO-L-Ser-KM.This system was then applied to control two prevalent species of tobacco brown spot pathogens(Alternaria longipes and Alter n aria alternata).The results indicated that the SEM,FT-IR and XDR characterizations demonstrated the successful preparation of GO-L-Ser-KM,with a drug-loading rate of 152.96％.Under diverse pH conditions,the system effectively achieved controlled and sustained release of the pesticide,while simultaneously enhanced the photolysis resistance and dispersion stability of KM.Compared with KM alone,GO-L-Ser-KM exhibited superior wetting ability on tobacco leaves and significantly improved the resistance to rainwater wash-off.Moreover,GO-L-Ser-KM demonstrated more potent antibacterial activity against the tobacco brown spot pathogens.It effectively reduced the half-maximal effective concentration(EC50)of the pesticide,with a synergistic ratio(SR)value exceeding 1.5.This indicated that GO-L-Ser-KM not only exerted a synergistic bactericidal effect but also possessed a targeted adsorption capacity for pathogenic spores.In addition,GO-L-Ser displayed excellent biosafety towards tobacco and mung beans.By encapsulating KM,the biotoxicity of KM was mitigated to a certain extent.Overall,it was highly anticipated that GO-L-Ser-KM would hold great potential and broad application prospects in terms of functional release,improving the comprehensive performance of pesticides,and achieving highly efficient disease control.关键词
纳米农药/氧化石墨烯/pH控释/烟草赤星病Key words
Nano-pesticide/Graphene oxide/pH-Controlled release/Tobacco brown spot分类
农业科技引用本文复制引用
赵庆训,鲁冠麟,宋赛杰,刘健锋,孙光军,杨茂发,尹贵吉,沈健,艾永峰,文贇..pH响应型GO-L-Ser-KM纳米农药制备及其对烟草赤星病的防控[J].山东农业科学,2025,57(6):121-132,12.基金项目
中国烟草总公司贵州省公司科技项目(20240069) （20240069）
国际联合科研项目(202201) （202201）
