山东医药2025，Vol.65Issue(7)：20-23,4.DOI:10.3969/j.issn.1002-266X.2025.07.005
脑梗死后认知功能障碍患者血清γ分泌酶水平变化及梗死部位观察
Changes in serum γ-secretase levels and observation of infarct locations in patients with cognitive dysfunction after cerebral infarction
摘要
Abstract
Objective To observe the changes in serum γ-secretase levels in patients with cognitive dysfunction fol-lowing cerebral infarction,to analyze the predictive value of serum γ-secretase levels for the occurrence of cognitive dys-function after cerebral infarction,and to examine the locations of the infarction.Methods A total of 114 patients with ce-rebral infarction admitted to the Second People's Hospital of Guizhou Province from June 2021 to May 2024 were selected,and we evaluated the patients with cerebral infarction using the Mini-Mental State Examination(MMSE),and then the 114 patients were divided into the cognitive dysfunction group(54 cases,MMSE score<27 points)and normal cognitive func-tion group(60 cases,MMSE score≥27 points).The serum γ-secretase was detected by ELISA,and the receiver operat-ing characteristic(ROC)curve was plotted.The predictive value of serum γ-secretase level on cognitive dysfunction after cerebral infarction was analyzed,and the infarct location was observed.Results The serum γ-secretase levels in the cog-nitive dysfunction group and the normal cognitive function group were(906.63±271.60)and(627.26±254.38)pg/mL,respectively,with statistically significant difference between the two groups(P<0.05).The AUC of serum γ-secretase level in predicting cognitive dysfunction after cerebral infarction was 0.783(95%CI:0.698-0.867),and the sensitivity and specificity were 0.833 and 0.650,respectively,when the optimal cut-off value was 722.79 pg/mL.In the group with cog-nitive functional impairment,there were 21 cases(38.89%)with infarction locations involving the frontal lobe and 33 cases(61.11%)involving other regions.In the group with normal cognitive function,there were 11 cases(18.33%)and 49 cases(81.67%)respectively;there were significant differences between the two groups(all P<0.05).Conclusion The serumγ-secretase level increases in patients with cerebral infarction,which has a certain predictive value for cognitive dysfunc-tion after cerebral infarction.When the infarct location is the frontal lobe,cognitive impairment may be more likely to oc-cur.关键词
脑梗死/认知功能障碍/γ分泌酶/脑梗死部位Key words
cerebral infarction/cognitive dysfunction/γ-secretase/location of cerebral infarction分类
医药卫生引用本文复制引用
赵远琴,何燕青,林静,韩小娟..脑梗死后认知功能障碍患者血清γ分泌酶水平变化及梗死部位观察[J].山东医药,2025,65(7):20-23,4.基金项目
贵州省卫生健康委科学技术基金项目(gzwkj2021-012). （gzwkj2021-012）
