上海预防医学2025，Vol.37Issue(5)：436-440,5.DOI:10.19428/j.cnki.sjpm.2025.24453
甘油三酯-葡萄糖指数与中老年高血压人群脑卒中风险的队列研究
A cohort study of triglyceride-glucose index and risk of stroke in middle-aged and elderly individuals with hypertension
摘要
Abstract
[Objective]To investigate the association between triglyceride-glucose(TyG)index and the risk of stroke in middle-aged and elderly individuals with hypertension,so as to provide more evidence for the prevention and treatment of stroke.[Methods]Middle-aged and elderly hypertensive individuals who took part in all four surveys in 2011,2013,2015,and 2018 were selected as the research subjects based on data from the China Health and Retirement Longitudinal Study(CHARLS).Participants were divided into four groups(≤Q1,>Q1～Q2,>Q2～Q3,and>Q3)based on TyG index quartiles,and the cumulative risk of stroke in different groups was analyzed using the Kaplan-Meier method.Different Cox proportional hazards regression models were constructed to analyze the relationship between the TyG index and stroke risk.Sensitivity analysis were performed to evaluate the robustness of the results.[Results]A total of 4 596 participants were included in the study.Among them,338 individuals(7.35%)had a stroke during the 7-year follow-up period.The cumulative risk of stroke increased with higher TyG index levels.Results from the Cox regression models indicated that higher TyG levels were associated with an increased risk of stroke among middle-aged and elderly individuals with hypertension.Compared with the lowest TyG index quartile(≤Q1:TyG index≤8.33)group,the highest quartile(>Q3:TyG index>9.17)group showed a 45.10%increased risk of stroke(HR=1.451,95%CI:1.017‒2.072).[Conclusion]A higher TyG index is associated with an increased risk of stroke in middle-aged and elderly individuals with hypertension.关键词
甘油三酯-葡萄糖指数/中老年/高血压/脑卒中/队列研究Key words
triglyceride-glucose index/middle and old age/hypertension/stroke/cohort study分类
医药卫生引用本文复制引用
陈红艳,方奎,张洁..甘油三酯-葡萄糖指数与中老年高血压人群脑卒中风险的队列研究[J].上海预防医学,2025,37(5):436-440,5.基金项目
辽宁省教育厅2020年度科学研究经费资助项目(FWZR2020004) （FWZR2020004）
