上海针灸杂志2025，Vol.44Issue(7)：810-815,6.DOI:10.13460/j.issn.1005-0957.2025.13.4041
穴位埋线治疗肥胖症伴胰岛素抵抗的疗效观察及对血清PPARγ、NF-κB的影响
Clinical observation on the efficacy of acupoint catgut embedding in the treatment of obesity with insulin resistance and its effect on serum PPARγ and NF-κB levels
摘要
Abstract
Objective To observe the clinical efficacy of acupoint catgut embedding in the treatment of obesity with insulin resistance(IR)and its effect on serum peroxisome proliferator-activated receptor gamma(PPARγ)and nuclear factor-kappa B(NF-κB)levels.Method A total of 76 patients were randomly divided into a control group and an observation group,with 38 cases in each group.The control group received dietary and exercise interventions,while the observation group received additional acupoint catgut embedding therapy.The body mass index(BMI),waist-to-hip ratio(WHR),body fat percentage,levels of serum total cholesterol(TC)and triglycerides(TG),fasting plasma glucose(FPG),fasting insulin(FINS),and homeostasis model assessment for insulin resistance(HOMA-IR)were observed in the two groups.Serum levels of PPARγ and NF-κB were also assessed.Result The BMI of the control group was significantly reduced after treatment(P＜0.05),and the differences in WHR and body fat percentage were not statistically significant compared with the pre-treatment(P＞0.05);the BMI,WHR and body fat percentage of the observation group were significantly reduced after treatment(P＜0.05)and lower than those of the control group(P＜0.05).The differences of TC and TG levels in the control group after treatment were not statistically significant compared with the pre-treatment(P＞0.05);TC and TG levels in the observation group were significantly reduced after treatment(P＜0.05),and lower than those of the control group(P＜0.05).FPG,FINS and HOMA-IR were reduced in both groups after treatment(P＜0.05),and those of the observation group were lower than those of the control group(P＜0.05).The differences in serum PPARg and NF-κB levels in the control group after treatment were not statistically significant compared with the pre-treatment(P＞0.05),while serum PPARg level in the observation group was significantly higher after treatment(P＜0.05),the level of NF-κB was significantly lower(P＜0.05),and both of them were better than those of the control group(P＜0.05).Conclusion Acupoint catgut embedding therapy in the treatment of obesity with IR can effectively reduce BMI,WHR,and body fat percentage,regulate lipid metabolism,and improve IR.These effects may be related to the regulation of serum PPARγ and NF-κB levels,and the treatment is superior to dietary and exercise interventions alone.关键词
埋藏疗法/埋线/肥胖/胰岛素抵抗/过氧化物酶体增殖物激活受体γ/核因子κBKey words
Embedding therapy/Embedding,thread/Obesity/Insulin resistance/Peroxisome proliferator-activated receptor gamma/Nuclear factor-kappa B分类
医药卫生引用本文复制引用
王瑶,梁爽,冯鑫鑫,张奕,陈雷..穴位埋线治疗肥胖症伴胰岛素抵抗的疗效观察及对血清PPARγ、NF-κB的影响[J].上海针灸杂志,2025,44(7):810-815,6.基金项目
浙江省中医药科技计划项目(2021ZB256) （2021ZB256）
宁波市医学重点学科建设项目(2022-ZF01) （2022-ZF01）
浙江省陈雷名中医药专家传承工作室 （）
宁波市张奕名中医药专家传承工作室 （）
