世界科学技术-中医药现代化2025，Vol.27Issue(7)：1801-1814,14.DOI:10.11842/wst.20241024006
中药防治肠缺血再灌注损伤研究进展
Research Progress on the Prevention and Treatment of Intestinal Ischemia-reperfusion Injury with Traditional Chinese Medicine
摘要
Abstract
Ischemic bowel disease(IBD)is a prevalent intestinal vascular disease that poses a serious threat to patients' lives and health.Tthe key pathological process of ischemic bowel disease is intestinal ischemia-reperfusion(II/R)injury.If not diagnosed and treated in a timely manner,it can lead to life-threatening conditions such as peritonitis,intestinal gangrene perforation,and multiple organ dysfunction.Current treatments primarily focus on symptomatic and surgical interventions,lacking targeted pharmacological therapies.A substantial body of research has found that traditional Chinese medicine(TCM)exhibits a protective effect against II/R injury.This review systematically elaborated on the mechanisms by which various TCM bioactive components,including Astragaloside IV,Ginsenosides,Salvianolic acids,and Tetramethylpyrazine,as well as compound formulations such as Shenqi injection,Taoren Chengqi decoction,and Sini decoction ameliorate II/R injury.These findings provide novel research perspectives for developing TCM-based therapeutics for IBD.关键词
中药活性成分/中成药/肠缺血再灌注损伤/机制Key words
Active components of traditional Chinese medicine/Chinese patent medicines/Intestinal ischemia-reperfusion injury/Mechanisms分类
医药卫生引用本文复制引用
吴柯,张正雨,王秋玲,刘孟楠,任维,郭伍斌..中药防治肠缺血再灌注损伤研究进展[J].世界科学技术-中医药现代化,2025,27(7):1801-1814,14.基金项目
四川省中医药管理局面上项目(2024MS151):膈下逐瘀颗粒通过TLR4/NF-κB信号通路对小肠缺血再灌注损伤的保护作用及其临床疗效评价研究,负责人:郭伍斌. （2024MS151）
