世界科学技术-中医药现代化2025，Vol.27Issue(7)：1906-1913,8.DOI:10.11842/wst.20250127003
基于中西医临床病证特点的甲状腺功能减退症动物模型分析
Analysis of Animal Models of Hypothyroidism Based on Clinical Characteristics of Traditional Chinese and Western Medicine
摘要
Abstract
Objective Hypothyroidism is a common clinical disease of systemic metabolic reduction,the incidence and detection rate increased year by year.Based on the clinical characteristics of hypothyroidism,the study constructed and improved animal models to provide reference for the study of hypothyroidism prevention and treatment.Methods By reviewing relevant domestic and foreign literatures,the modeling methods of hypothyroidism were summarized and analyzed.According to the etiology,pathogenesis and clinical diagnostic criteria of hypothyroidism in Chinese medicine and Western medicine,the modeling methods and principles of hypothyroidism animal models were summarized,and the advantages and disadvantages of animal models and the evaluation of clinical conformity were analyzed.Results It was found that the model of drug induction,iodine restriction and 131 I-induced hypothyroidism had high clinical anastomosis in Western medicine,and had the advantages of simple operation,high model formation rate and good repeatability,the combination of the disease model and the syndrome model of kidney yang deficiency and spleen and kidney yang deficiency have a high degree of clinical conformity in TCM.Congenital induced hypothyroidism,autoimmune induced hypothyroidism and genetic induced hypothyroidism can be studied for their unique etiology and pathogenesis,but their clinical manifestations are relatively simple and their clinical anastomosis is relatively low.At present,the construction of hypothyroidism animal model is mainly based on the pathogenesis of Western medicine,and the evaluation of the model mostly relies on laboratory detection indicators.The clinical anastomosis score of traditional Chinese medicine is generally low,and the record of animal apparent indicators is generally insufficient.Conclusion In the process of building hypothyroidism animal model,based on the pathogenesis of traditional Chinese medicine,combining the etiology of traditional Chinese medicine and the pathogenesis of Western medicine,multi-factor comprehensive modeling method can be adopted to increase the record of apparent indicators,improve the accuracy of the four diagnoses and symptoms of traditional Chinese medicine,and systematically and dynamically observe the interaction process of disease and syndrome,so as to build an animal model of hypothyroidism which is more closely aligns with with the clinical characteristics of traditional Chinese medicine and Western medicine.关键词
甲状腺功能减退/中西医临床/病证特点/动物模型/临床吻合度/模型分析Key words
Hypothyroidism/Clinical practice of Chinese and Western medicine/Characteristics of disease and syndrome/Animal model/Clinical anastomosis/Model analysis分类
医药卫生引用本文复制引用
陈号,谢逸轩,成哲,孙婧,陆逸凡,周希乔..基于中西医临床病证特点的甲状腺功能减退症动物模型分析[J].世界科学技术-中医药现代化,2025,27(7):1906-1913,8.基金项目
国家自然科学基金委员会青年科学基金项目(82203850):SPP1通过CD44/PI3K/AKT介导甲状腺乳头状癌干性转化促进侵袭转移的机制研究,负责人:孙婧 （82203850）
江苏省中医院高峰学术人才项目(Y2021RC22):代谢性脂肪肝的基础与临床研究,负责人:周希乔. （Y2021RC22）
