世界科学技术-中医药现代化2025，Vol.27Issue(7)：1914-1921,8.DOI:10.11842/wst.20240905004
白血病动物模型特点及应用分析
Evaluation of Characteristics of Animal Models of Leukemia Based on Data Mining
摘要
Abstract
Objective To provide a reference basis for the establishment of ideal animal models of leukemia,the characteristics of animal models of leukemia was summarized.Methods The themes of"leukemia"and"animal"were searched in CNKI databases.The relevant literature on animal experiments of leukemia from January 2010 to August 2024 were screened.And a database by Excel 2017 tables was established by organizing their research animal strains,modeling methods and testing indexes to analyze the characteristics of leukemia animal models.Results After comparative analysis,it was found that the animal strains in modeling were BALB/C-nude mice(40 times,29.86%)and NOD/SCID mice(32 times,23.88%),respectively.The modeling method was transplanted cells(127 times,93.38%),and the detection indexes were pathological tissues(80 times,14.84%),blood smears(75 times.13.91%),general condition(73 times,13.54%),bone marrow smear(73 times,13.54%),flow cytometry(55 times,10.20%),blood routine(50 times,9.28%).Conclusion The existing animal models of leukemia are complex and diverse.关键词
白血病/动物模型/评价指标/数据挖掘Key words
Leukemia/Animal models/Evaluation indicators/Data mining分类
医药卫生引用本文复制引用
佘琳静,屈秉聪,周天豹,郭琳,谢逸轩,白明,苗明三..白血病动物模型特点及应用分析[J].世界科学技术-中医药现代化,2025,27(7):1914-1921,8.基金项目
国家自然科学基金委员会重大课题(82074038):基于体表神经-内分泌-免疫网络的白芷外治黄褐斑分子机制研究,负责人:苗明三 （82074038）
河南省科学技术厅河南省重大公益专项(201300310100):豫产道地中药材资源综合利用中心,负责人:苗明三 （201300310100）
国家中医药管理局(国中医药人教函2022-6):岐黄学者,负责人:苗明三. （国中医药人教函2022-6）
