世界中西医结合杂志2025，Vol.20Issue(6)：1089-1095,7.DOI:10.13935/j.cnki.sjzx.250604
从脾胃论治失眠的临床疗效Meta分析及组方用药规律研究
Meta-Analysis of Clinical Efficacy and Prescription Patterns of Treating Insomnia from Perspective of Spleen and Stomach Theory
摘要
Abstract
Objective This paper aims to conduct a systematic review and meta-analysis on the efficacy and safety of traditional Chinese medicine(TCM)in the treatment of insomnia based on spleen and stomach theory and explore the clinical medication patterns of this treatment using data mining techniques,so as to objectively explain its significance in clinical application and promotion.Methods A computerized search was conducted in Chinese and English databases including CNKI,Wanfang Data,VIP,CBM,PubMed,Embase,and the Cochrane Library from inception to November 20,2024,for randomized controlled trials on treating insomnia based on spleen and stomach theory.Search terms included"in-somnia,spleen tonifying,stomach harmonizing,traditional Chinese medicine,and randomized controlled trial"in both Chi-nese and English.References that met the inclusion criteria were screened,and data extraction and risk-of-bias assess-ment were carried out.Outcome indicator data were pooled for analysis,and the data of traditional Chinese medicine pre-scriptions were analyzed.Results A total of 18 studies involving 1 907 patients were included,with 1 004 in the treatment group and 903 in the control group.The total clinical effective rate of the treatment group was higher than that of the control group[RR=1.10,95％CI(1.05,1.15),P＜0.000 1].The PSQI scores after treatment were lower in the treatment group than in the control group[MD=-2.01,95％CI(-2.96,-1.06),P＜0.000 1].Improvement in TCM syndrome scores was better in the control group,and the incidence of adverse reactions was relatively lower.A total of 57 Chinese herbs were involved in the analysis of medication patterns,with a cumulative frequency of210 occurrences.Among them,11 herbs were used more than five times,including including Ziziphi Spinosae Semen,Glycyrrhizae Radix et Rhizoma,Atractylodis Macro-cephalae Rhizoma,Polygoni Multiflori Caulis,Pinelliae Rhizoma,Poria Cum Radix Pini,Angelicae Sinensis Radix,Poria,Polygalae Radix,Citri Reticulatae Pericarpium,and Astragali Radix.Association rule analysis showed high support and con-fidence for herb combinations such as Ziziphi Spinosae Semen-Polygoni Multiflori Caulis-Glycyrrhizae Radix et Rhizo-ma,Ziziphi Spinosae Semen-Poria Cum Radix Pini,Glycyrrhizae Radix Et Rhizoma-Angelicae Sinensis Radix,and Pinelliae Rhizoma-Citri Reticulatae Pericarpium.Conclusion Treating insomnia from spleen and stomach theory has good clinical efficacy and safety.The clinical prescriptions are mainly invigorating the spleen and Qi,combined with nouris-hing the blood and resolving phlegm.This approach is suitable for broader clinical application but still needs to be further verified by higher-quality clinical studies.关键词
失眠/脾胃/Meta分析/系统综述/数据挖掘Key words
Insomnia/Spleen and Stomach/Meta-Analysis/Systematic Review/Data Mining分类
医药卫生引用本文复制引用
李泓瑶,郭蓉娟..从脾胃论治失眠的临床疗效Meta分析及组方用药规律研究[J].世界中西医结合杂志,2025,20(6):1089-1095,7.基金项目
国家自然基金区域联合重点项目(U21A20401) （U21A20401）
