世界中医药2025，Vol.20Issue(10)：1694-1698,5.DOI:10.3969/j.issn.1673-7202.2025.10.008
玉屏风合二陈散减少咳嗽变异性哮喘炎症反应的机制研究
Mechanism of Yupingfeng Combined with Erchen Powder in Reducing Inflammatory Response in Cough Variant Asthma
摘要
Abstract
Objective:To explore the mechanism by which Yupingfeng combined with Erchen Powder alleviates inflammatory re-sponses in a rat model of cough variant asthma(CVA)by targeting NOD-like receptor protein 3(NLRP3),apoptosis-associated speck-like protein(ASC),and caspase-1.Methods:Healthy male rats were divided into control,model,dexamethasone,and Yup-ingfeng+Erchen Powder group.A CVA model was established using ovalbumin(OVA)and aluminum hydroxide sensitization.Pul-monary inflammation was assessed by hematoxylin-eosin(HE)staining.Serum levels of interleukin(IL-1β)and IL-18 were meas-ured using enzyme-linked immunosorbent assay(ELISA).The expression of NLRP3,ASC,and caspase-1 at both mRNA and protein levels in lung tissues was evaluated by real-time quantitative PCR and Western blot.Results:Yupingfeng combined with Erchen Powder alleviated lung tissue inflammation in CVA rats,significantly reduced serum levels of the inflammatory cytokines IL-1β and IL-18,and downregulated the mRNA and protein expression of NLRP3,ASC,and caspase-1 in lung tissues.Conclusion:Yuping-feng combined with Erchen Powder may exert therapeutic effects on CVA by attenuating inflammatory responses through the down-regulation of NLRP3,ASC,and caspase-1 expression.关键词
玉屏风散/二陈散/大鼠/咳嗽变异性哮喘/NOD样受体热蛋白结构域相关蛋白3/胱天蛋白酶-1/凋亡相关斑点样蛋白/炎症反应Key words
Yupingfeng Powder/Erchen Powder/Rats/Cough variant asthma/NOD-like receptor protein 3/Caspase-1/Apopto-sis-associated speck-like protein/Inflammatory response分类
医药卫生引用本文复制引用
于素平,任献青,徐炎,宋桂华,张岩,吕伟刚,陈小松,彭明浩..玉屏风合二陈散减少咳嗽变异性哮喘炎症反应的机制研究[J].世界中医药,2025,20(10):1694-1698,5.基金项目
国家中医药管理局中医药循证能力建设专科专病循证能力提升项目(2019XZZX-EK002) （2019XZZX-EK002）
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
河南省卫生健康委员会国家中医临床研究基地科研专项(2021JDZY002) （2021JDZY002）
河南省卫生健康委员会国家中医药传承创新科研专项(2023ZXZX1010) （2023ZXZX1010）
