生命科学研究2025，Vol.29Issue(3)：189-197,9.DOI:10.16605/j.cnki.1007-7847.2024.08.0175
赖氨酸巴豆酰化修饰在动物生理发育和疾病发生中的作用与机制
Roles and Mechanisms of Lysine Crotonylation in Animal Physiological Development and Disease Occurrence
摘要
Abstract
Lysine crotonylation is a newly discovered posttranslational modification,which plays an impor-tant role in human physiological development and disease occurrence.This review summarized the molecular mechanisms of enzymatic and metabolic regulation in the reversible process of lysine crotonylation,and also discussed how dynamic changes of crotonylation influence animal physiological development and pathogene-sis.Although the research on lysine crotonylation has achieved remarkable progress,there is still conside-rable unknown territory in this field.In future research,identifying specific regulatory proteins for lysine crotonylation and developing therapeutic strategies through modulating cellular lysine crotonylation levels would be particularly prioritized.关键词
表观遗传学/蛋白质翻译后修饰/赖氨酸巴豆酰化/生理发育/疾病发生Key words
epigenetics/posttranslational modification/lysine crotonylation/physiological development/di-sease occurrence分类
生物科学引用本文复制引用
侯连杰,方彰胜,谢梅英..赖氨酸巴豆酰化修饰在动物生理发育和疾病发生中的作用与机制[J].生命科学研究,2025,29(3):189-197,9.基金项目
广东省自然科学基金项目(2023A1515010582) （2023A1515010582）
广东省科技计划项目(2023A1414020003) （2023A1414020003）
广东省普通高校重点科研项目(2024ZDZX2110) （2024ZDZX2110）
