生命科学研究2025，Vol.29Issue(3)：198-206,215,10.DOI:10.16605/j.cnki.1007-7847.2024.07.0162
线粒体内膜蛋白在线粒体生物学功能及相关疾病中的研究进展
Research Progress of Inner Membrane Mitochondrial Protein in Biological Functions of Mitochondria and Related Diseases
郝文静 1冯红1
作者信息
- 1. 天津体育学院天津市运动生理学与运动医学重点实验室,中国 天津 301617
- 折叠
摘要
Abstract
Mitochondria are semi-autonomous organelles with a double-membrane structure central to in-tracellular energy production,metabolism,and signal transduction.The inner membrane mitochondrial pro-tein(IMMT)is a critical transmembrane protein required for mitochondrial structure,and its abnormal expres-sion,deletion,or mutation will lead to abnormal mitochondrial structure,affecting mitochondrial function.Based on the biological significance of IMMT in mitochondria,the review systematically elucidates the bio-logical functions of IMMT in protein import,mitochondrial dynamics,mitophagy,apoptosis,and related di-seases,offering novel perspectives for treating these diseases through IMMT-mediated mitochondrial regulation.关键词
线粒体内膜蛋白(IMMT)/蛋白质输入/线粒体动力学/线粒体自噬/细胞凋亡/神经退行性疾病/代谢性疾病Key words
inner membrane mitochondrial protein(IMMT)/protein import/mitochondrial dynamics/mito-phagy/apoptosis/neurodegenerative disease/metabolic disease分类
生物科学引用本文复制引用
郝文静,冯红..线粒体内膜蛋白在线粒体生物学功能及相关疾病中的研究进展[J].生命科学研究,2025,29(3):198-206,215,10.
