生物技术通报2025，Vol.41Issue(7)：1-16,16.DOI:10.13560/j.cnki.biotech.bull.1985.2024-1265
植物CBL调控逆境胁迫响应的作用机制
Functional Mechanism of Plant CBL in Regulating the Responses to Abiotic and Biotic Stresses
摘要
Abstract
Calcineurin B like protein(CBL)is a kind of specific Ca2+sensor in plants,which plays a crucial role in plant growth and development,and the response to environmental stresses.CBL is composed of four typical elongation factor hands(EF-hands)domains for Ca2+binding.Each EF-hand is α-helix-loop-α-helix structures composed of 12 relatively conserved amino acids.The cis-acting regulatory elements(such as W-box,MBS and G-BOX)in the promoter region of CBL can bind with upstream transcription factors(TFs)to regulate transcription by activating or inhibiting the expression of downstream genes.CBL is involved in the regulation of signaling pathways such as abscisic acid(ABA),hormones,respiratory burst oxidases homolog(RBOH),and reactive oxygen species(ROS),to reduce water evaporation,thereby adapting various abiotic stresses.There are evidences that CBL can rapidly perceive changes in the transient intracellular Ca2+signal when plants were subjected to abiotic and biotic stresses such as salt,drought,extreme temperature,nutrient stress and pathogen.CBLs not only interact with CBL-interacting protein kinase CIPK to phosphorylate downstream target proteins for calcium signal transduction,but also interact with other proteins(such as high-affinity K+transporter 5,protein S-acyl transferase10 and type 2C protein phosphatases),thereby positively or negatively regulating stress tolerance in plant.Additionally,CBL mediates the growth and development of plant organs and tissues and promotes fruit ripening by regulating sugar signals.CBL also interacts with gigantea(GI)to affect the flowering time of plants.In this review,recent research findings on the discovery,structure,classification,regulatory mechanisms and roles of plant CBL in regulating the response to adversity stresses are summarized,and its future research directions are prospected,aiming to provide the gene resources and the theoretical basis for improving tolerance of crops and biological breeding to stress.关键词
钙调磷酸酶B样蛋白/调控机制/蛋白互作/生长发育/抗逆性/顺式调控元件/蛋白激酶Key words
calcineurin B like protein/regulatory mechanism/protein-protein interaction/growth and development/stress tolerance/cis-acting regulatory elements/protein kinase引用本文复制引用
王从欢,伍国强,魏明..植物CBL调控逆境胁迫响应的作用机制[J].生物技术通报,2025,41(7):1-16,16.基金项目
国家自然科学基金项目(32360483,32160466),甘肃省自然科学基金重点项目(23JRRA764),甘肃省省级生态文明建设重点研发专项(25YFFA011) （32360483,32160466）
