生物技术通报2025，Vol.41Issue(7)：60-68,9.DOI:10.13560/j.cnki.biotech.bull.1985.2024-0947
植物接头蛋白复合体TPC的研究进展
Research Progress in Adaptor Protein Complex TPC in Plants
摘要
Abstract
Clathrin-mediated endocytosis(CME)is a predominant endocytic pathway for plasma membrane(PM)protein internalization in eukaryotic cells.In plants,CME is essential for growth and developmental processes,nutrient uptake,transduction between extra-and intra-cellular signals,polar auxin transport,and stress responses.Although clathrin is the core protein of the CME process,it lacks a transmembrane domain and relies on adaptor proteins to be recruited to the PM.It is known that the PM recruitment of clathrin mainly depends on the adaptor protein complex AP-2 in animal and plant cells.However,an increasing number of evidences on plant adaptor protein complexes show that there is also an evolutionary ancient adaptor protein complex TPC(TPLATE complex)in plants,which plays a critical role in plant growth and development as well as CME processes.In this review,we briefly introduce the composition,structure,and evolutionary history of TPC in plants.Then we analyze the domains of TPC subunits.Furthermore,we summarize the biological functions of TPC.Finally,we prospect the research on TPC in plant endocytosis and growth and development,aiming to provide new ideas and insights for understanding and clarifying the molecular mechanism of plant TPC in endocytic transport.关键词
接头蛋白复合体/TPC/网格蛋白/胞吞途径Key words
adaptor protein complex/TPC(TPLATE complex)/clathrin/endocytosis引用本文复制引用
王玉同,张颖慧,徐梅,严旭,赵菲佚,田丹..植物接头蛋白复合体TPC的研究进展[J].生物技术通报,2025,41(7):60-68,9.基金项目
国家自然科学基金项目(32200607),甘肃省科技计划资助项目(24JRRE005),天水师范学院科研项目(KYQ2023-16) （32200607）
