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Dual distal insertions drive pimarane-to-miltiradiene rearrangement with enhanced enzymatic activity

Jianing Liu Jian Wang Guanghong Cui Haiyan Zhang Mei Tian Ying Zheng Baolong Jin Luqi Huang

生物设计研究（英文）2025，Vol.7Issue(2)：55-62,8.

生物设计研究（英文）2025，Vol.7Issue(2)：55-62,8.DOI:10.1016/j.bidere.2025.100028

Dual distal insertions drive pimarane-to-miltiradiene rearrangement with enhanced enzymatic activity

Jianing Liu ¹Jian Wang ¹Guanghong Cui ¹Haiyan Zhang ²Mei Tian ¹Ying Zheng ³Baolong Jin ¹Luqi Huang¹

作者信息

1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
2. Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing,100700,China
3. Guangzhou University of Chinese Medicine,Guangzhou,510006,China
折叠

摘要

关键词

Diterpene synthase/Miltiradiene/Prokaryotic expression/Site-directed mutagenesis/Enzymatic properties

Key words

Diterpene synthase/Miltiradiene/Prokaryotic expression/Site-directed mutagenesis/Enzymatic properties

引用本文复制引用

Jianing Liu,Jian Wang,Guanghong Cui,Haiyan Zhang,Mei Tian,Ying Zheng,Baolong Jin,Luqi Huang..Dual distal insertions drive pimarane-to-miltiradiene rearrangement with enhanced enzymatic activity[J].生物设计研究（英文）,2025,7(2):55-62,8.

基金项目

We sincerely thank Reuben J.Peters from Iowa State University for providing the modular metabolic engineering system.This work was supported by Key project at central government level:the ability to establish sustainable use of valuable Chinese Medicine Resources(2060302),National Natural Science Foundation of China(82274054 and 82204573),Scientific and technological innovation project of China Academy of Chinese Medical Science(CI2023E002),Guangdong Pro-vincial Bureau of Traditional Chinese Medicine Research Foundation(20251101). （2060302）

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