Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation
Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation
摘要
关键词
Mitofusin-2(MFN2)/Charcot-Marie-Tooth disease type 2A(CMT2A)/Mitochondrial fusion/Small molecule compounds/Screening and evaluation platform/CMT2A neuronal systemKey words
Mitofusin-2(MFN2)/Charcot-Marie-Tooth disease type 2A(CMT2A)/Mitochondrial fusion/Small molecule compounds/Screening and evaluation platform/CMT2A neuronal system引用本文复制引用
Yang Liu,Yubo Zhang,Ran Sui,Guo Chen,Xiaojiang Hao,Quan Chen,Chen Yan,Borui Cao,Dejun Kong,Jiaqi Li,Wenlei Li,Yingjie Guo,Zhongyang Yuan,Yumiao Gao..Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation[J].生物物理学报（英文）,2025,11(3):143-155,13.基金项目
We thank Zhixing Chen at Peking Universi-ty National Biomedical Imaging Center for the provision of the live-cell mitochondrial probe PK MitoTracker Orange （）
David Chan at California Institute of Technology for providing the Mitofusin knock-out MEFs.Our confocal microscope imaging work was performed at the State Key Laboratory of Medicinal Chemical Biology Microscope Imaging Platform at Nankai Uni-versity.This work was supported by the Yunnan Provincial Sci-ence and Technology Project at Southwest United Graduate School(202402AQ370001),the National Natural Science Foun-dation of China(32400569,32230046,82293683 and 92357302),the Ministry of Science and Technology of China(2021YFC2700903),the Key Research and Development Project of Yunnan Province(202003AD150012),the Key Projects of Tianjin Science and Technology(24ZXZSSS00150),China Post-doctoral Science Foundation(2021M691666),Tianjin Natural Science Foundation(23JCQNJC01730)and"the Fundamental Re-search Funds for the Central Universities",Nankai University(63231199,63241207 and 63241544). （202402AQ370001）
