护理研究2025，Vol.39Issue(14)：2344-2350,7.DOI:10.12102/j.issn.1009-6493.2025.14.004
宫颈癌术后病人下肢淋巴水肿风险预测模型的构建
Development of hazards prediction model for lower limb lymphedema in postoperative cervical cancer patients
摘要
Abstract
Objective:To explore the influencing factors of lower limb lymphedema in postoperative cervical cancer patients and to construct a Cox proportional-hazards prediction model.Methods:A total of 303 postoperative cervical cancer patients admitted to a cancer hospital in Hunan province were selected for study subjects from July 2020 to June 2021.Predictors were screened using LASSO regression and Cox regression analysis.The Cox proportional-hazards prediction model was constructed.Then the Nomogram was constructed.The model's discriminative ability and predictive performance were evaluated using the C-index,calibration curve,and area under the curve of receiver operator characteristic.Results:The result of Cox regression analysis showed that 5 variables were retained,namely hypertension,postoperative concurrent chemoradiotherapy,prolonged static posture after surgery,postoperative physical labor intensity and whether exercise regularly after surgery.Based on literature review and expert consultation,2 additional variables(number of pelvic lymph nodes removed and postoperative radiation dose)were incorporated to construct the Cox proportional-hazards prediction model.The Nomogram was also constructed.The C-index was 0.858(95%CI 0.784-0.932)in the test set.The area under the curve of receiver operator characteristic at 1 year and 2 years time points were 0.920 and 0.881,respectively.And the calibration curve demonstrated good agreement between predicted and observed outcomes.Conclusions:The Cox proportional-hazards prediction model for lower limb lymphedema in postoperative cervical cancer patients had good predictive performance.It could provide reference for early identification of high-risk patients and prevention and treatment of lower limb lymphedema in postoperative cervical cancer patients.关键词
宫颈癌/下肢淋巴水肿/影响因素/风险预测/列线图Key words
cervical cancer/lower limb lymphedema/influencing factors/risk prediction/Nomogram引用本文复制引用
李森,刘高明,赵国瑞,周颖..宫颈癌术后病人下肢淋巴水肿风险预测模型的构建[J].护理研究,2025,39(14):2344-2350,7.基金项目
2024年度湖南省自然科学基金面上项目,编号:2024JJ5242 （）
2023年度湖南省卫生健康高层次人才重大科研专项项目,编号:20230487 （）
2024年度湖南省卫生健康委卫生科研课题,编号:W20243226 （）
2024年湖南省护理学会科研课题,编号 （）
HNKY202405 （）
