护理研究2025，Vol.39Issue(15)：2535-2543,9.DOI:10.12102/j.issn.1009-6493.2025.15.005
肺癌病人免疫检查点抑制剂相关皮肤毒性护理方案的构建及应用
Construction and application of nursing programme for immune checkpoint inhibitors-related skin toxicity in lung cancer patients
摘要
Abstract
Objective:To construct a nursing programme for ICIs-related skin toxicity in lung cancer patients.To apply the programme initially and to evaluate its effect.Methods:Constructing a nursing programme for ICIs-related skin toxicity in lung cancer patients based on evidence-based nursing and Delphi method.A total of 112 lung cancer patients who received their first ICIs treatment in the oncology department of a tertiary A grade hospital from February to November 2023 were selected as the research subjects.They were divided into control group(59 cases)and test group(53 cases).The control group received routine care in the oncology department,while the test group received the nursing programme for ICIs-related skin toxicity in lung cancer patients.The incidence,severity of irCAEs,KPS scores between the two groups,and nurses'knowledge level of ICIs were compared.Results:After 2 rounds of Delphi expert inquiry,the final nursing programme for ICIs-related skin toxicity in lung cancer patients included 6 primary items and 19 secondary items.After implementing the nursing programme,the skin toxicity of the test group was milder than that of the control group(P<0.05).The KPS score was higher than that of the control group(P<0.05).The score of nurses'knowledge related to ICIs was higher than before implementation(P<0.05).Conclusions:The constructed nursing programme related to ICIs in lung cancer patients could improve the severity of the patient's skin,enhance their quality of life,and improve the knowledge level of nurses.关键词
肺癌/免疫检查点抑制剂/皮肤毒性/生活质量/循证护理/德尔菲法/护理Key words
lung cancer/immune checkpoint inhibitors/skin toxicity/quality of life/evidence-based nursing/Delphi method/nursing引用本文复制引用
郑金龙,郑雪梅,史君伟,张静,彭琪..肺癌病人免疫检查点抑制剂相关皮肤毒性护理方案的构建及应用[J].护理研究,2025,39(15):2535-2543,9.基金项目
长江大学医学部2022年研究生创新基金项目,编号:202210 （）
