现代检验医学杂志2025，Vol.40Issue(4)：13-17,5.DOI:10.3969/j.issn.1671-7414.2025.04.003
ATP2B2基因rs35678,rs2289274位点多态性与良性阵发性位置性眩晕的相关性研究
Correlation between Polymorphism at rs35678,rs2289274 Loci of ATP2B2 Gene and Benign Paroxysmal Positional Vertigo
摘要
Abstract
Objective To investigate the association between polymorphisms at the rs35678,rs2289274 loci of the ATPase plasma membrane Ca2+transporting 2(ATP2B2)gene and benign paroxysmal positional vertigo(BPPV).Methods 186 BPPV patients admitted to Xi'an Trade Union Hospital from January 2022 to January 2024 were selected as the BPPV group,and another 100 healthy individuals who underwent physical examination during the same period were selected as the control group.Polymerase chain reaction(PCR)was used to detect polymorphisms at the rs35678 and rs2289274 loci of the ATP2B2 gene.Allele and genotype frequencies were compared between the two groups.Unconditional Logistic regression was used to analyze the correlation with BPPV susceptibility under three genetic models(co-dominant,dominant and recessive)for the rs35678 and the rs2289274 loci.Results The distribution of genotypes at the rs35678 and rs2289274 loci of the ATP2B2 gene in the control group,and the BPPV group were all in accordance with the Hardy-Weinberg law of equilibrium(χ2=0.003～0.050,all P>0.05),and had a representativeness of the groups.Compared with the control group,the allele T frequency(56.45%vs 41.00%)and genotype TT frequency(31.87%vs 16.81%)were significantly higher in the BPPV group at the rs35678 locus,and the allele A frequency(54.30%vs 42.00%)and genotype AA frequency(29.48%vs 17.64%)at the rs2289274 locus,and the differences were statistically significant(χ2=3.936～12.290,all P<0.05).Under the codominant model(CC vs TT)for the rs35678 locus,carriers of TT genotype had an increased risk of disease compared to carriers of CC genotype(OR=1.851,95%CI:1.059～2.936);Under both the dominant model(CT+TT vs CC)and recessive model(CT+CC vs TT),the rs35678 polymorphism showed a statistically significant association with BPPV(OR=1.716,95%CI:1.074～2.936;OR=0.759,95%CI:0.517～0.837),and the differences were statistically significant(all P<0.05),reqectively.Under the codominant model(GG vs AA)for the rs2289274 locus,carriers of the AA genotype had a higher risk of disease compared to carriers of the GG genotype(OR=1.627,95%CI:1.191～2.973);in the dontinant model(AG+AA vs GG)the polymorphisms at the rs2289274 locus showed a significant association with BPPV(OR=1.941,95%CI:1.191～3.673),the differences were statistically significant(P<0.05).Conclusion The TT genotype at the rs35678 locus and the AA genotype at the rs2289274 locus of the ATP2B2 gene increase the risk of developing BPPV.关键词
良性阵发性位置性眩晕/单核苷酸多态性/钙离子转运ATP酶B2Key words
benign paroxysmal positional vertigo/single nucleotide polymorphism/ATPase plasma membrane Ca2+ transporting 2分类
医药卫生引用本文复制引用
吴江,郭海丽..ATP2B2基因rs35678,rs2289274位点多态性与良性阵发性位置性眩晕的相关性研究[J].现代检验医学杂志,2025,40(4):13-17,5.基金项目
陕西省科技厅重点研发计划项目-社会发展领域(项目编号:2022SF-563). （项目编号:2022SF-563）
