沈阳医学院学报2025，Vol.27Issue(4)：369-374,6.DOI:10.16753/j.cnki.1008-2344.2025.04.006
睡眠质量在社区轻度认知障碍老年人群血清维生素D3水平与抑郁症状间的中介作用
Mediating effect of sleep quality on the relationship between serum vitamin D3 level and depressive symptoms in community-dwelling elderly people with mild cognitive impairment
摘要
Abstract
Objective:To explore the mediating effect of sleep quality on the relationship between serum vitamin D3 level and depressive symptoms in community-dwelling elderly people with mild cognitive impairment(MCI).Methods:A total of 480 elderly people with MCI meeting inclusion criteria in a community health service center from Jan 2023 to Dec 2023 were selected as the research objects.The general information questionnaire,mini-mental state examination(MMSE),activity of daily living scale(ADL),Center for Epidemiological Studies Depression Scale(CES-D)and Pittsburgh sleep quality index(PSQI)were used to investigate the subjects.Serum vitamin D3 level was detected within 1 week.Spearson correlation analysis was used to explore the correlation between sleep quality,serum vitamin D3 level and depressive symptoms.The mediating effect model was tested by Model 4 in the Process plug-in.Results:Among the 480 MCI elderly,the average score of depression was(12.28±4.75),the average serum vitamin D3 level was(25.81±7.09)ng/ml,and the average score of sleep quality was(7.17±2.71).Depression severity was positively correlated with sleep quality score(r=0.294,P＜0.01),and negatively correlated with serum vitamin D3 level(r=-0.237,P＜0.01).Serum vitamin D3 level was negatively correlated with sleep quality score(r=-0.225,P＜0.01).Bootstrap analysis showed that the mediating effect of sleep quality between serum vitamin D3 level and depression level was-0.064(95%CI:-0.115--0.023),accounting for 26.57%of the total effect.Conclusion:Sleep quality partially mediates the relationship between serum vitamin D3 level and depressive symptoms in the elderly with MCI in the community.关键词
轻度认知障碍/睡眠质量/维生素D/抑郁/中介效应Key words
mild cognitive impairment/sleep quality/vitamin D/depression/mediating effect分类
医药卫生引用本文复制引用
董旭婷,蔡菡,汪啸虎,许慧,李世霞..睡眠质量在社区轻度认知障碍老年人群血清维生素D3水平与抑郁症状间的中介作用[J].沈阳医学院学报,2025,27(4):369-374,6.基金项目
安徽省高校自然科学研究项目(No.2023AH040381) （No.2023AH040381）
芜湖市卫健委重点项目(No.WHWJ2022z017) （No.WHWJ2022z017）
安徽省中医药高等专科学校自然科学研究重点项目(No.ZRKXZ202301) （No.ZRKXZ202301）
