沈阳医学院学报2025，Vol.27Issue(4)：375-379,5.DOI:10.16753/j.cnki.1008-2344.2025.04.007
我国老年脑卒中患者肺部感染的病原菌分布及耐药性变迁的荟萃分析
Meta-analysis of pathogen distribution and drug resistance trends in elderly patients with stroke-associated pneumonia in China
摘要
Abstract
Objective:To investigate the trends of pathogen distribution and drug resistance in elderly patients with stroke-associated pneumonia(SAP)in China,providing references for clinical antibiotic selection and application.Methods:A meta-analysis was conducted to comprehensively evaluate changes in resistance rates of major pathogens isolated from elderly SAP patients to key clinical antibiotics over the past 10 years.The trends of antimicrobial resistance were analyzed.Results:A total of 12 qualified articles were screened out,involving 1 202 cases of pulmonary infections and 1 315 pathogenic isolates.Gram-negative bacilli accounted for 951 strains(72.32%),Gram-positive cocci for 278 strains(21.14%),and fungi for 86 strains(6.54%).The top five pathogens were Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter Baumannii,Staphylococcus aureus and Escherichia coli.The resistance rates to various antibiotics showed minor fluctuations across years.Conclusions:Gram-negative bacilli dominate pulmonary infections in elderly stroke patients,with a high proportion of multidrug-resistant strains.Strengthened pathogen surveillance and rational antibiotic use are critical in clinical practice.关键词
老年人/脑卒中/肺炎/耐药Key words
elderly/stroke/pneumonia/drug resistance分类
医药卫生引用本文复制引用
崔斌,田志远,徐臣年,乔锐..我国老年脑卒中患者肺部感染的病原菌分布及耐药性变迁的荟萃分析[J].沈阳医学院学报,2025,27(4):375-379,5.基金项目
第74批中国博士后科学基金面上项目(No.2023M744296) （No.2023M744296）
陕西省自然科学基础研究计划(No.2024JC-YBQN-0793) （No.2024JC-YBQN-0793）
空军军医大学博士后启动项目(No.qd20230216) （No.qd20230216）
沈阳市科学技术计划公共卫生研发专项(联合项目)(No.24-214-3-151) （联合项目）
