实用医学杂志2025，Vol.41Issue(13)：1952-1957,6.DOI:10.3969/j.issn.1006-5725.2025.13.002
减瘤性肾切除术在转移性肾细胞癌治疗中的研究进展
The role and research progress of cytoreductive nephrectomy in metastatic renal cell carcinoma
摘要
Abstract
The treatment landscape for metastatic renal cell carcinoma(mRCC)has evolved rapidly over the past two decades with the introduction of targeted therapies and novel immune checkpoint inhibitors.Among these developments,cytoreductive nephrectomy(CN)remains a controversial and unresolved issue,with its survival benefits being questioned compared to systemic therapy(ST).The role and optimal timing of CN in the context of modern systemic treatment for mRCC remain unclear.Additionally,there is still no well-defined consensus on patient selection for CN.Therefore,this article provides a concise review of current evidence regarding CN in mRCC,incor-porating the latest renal cancer management guidelines.We focus particularly on optimal surgical timing,candidate patient selection,and the therapeutic value of metastasectomy.Furthermore,we examine the current role of CN in metastatic non-clear cell renal cell carcinoma and explore its evolving clinical applications and future prospects in mRCC treatment.关键词
转移性肾细胞癌/减瘤性肾切除术/靶向治疗/免疫治疗/转移瘤切除术Key words
metastatic renal cell carcinoma/cytoreductive nephrectomy/targeted therapy/immuno-therapy/metastasectomy分类
医药卫生引用本文复制引用
郭彩访,范宏,栾婷,詹辉,王海峰,王剑松..减瘤性肾切除术在转移性肾细胞癌治疗中的研究进展[J].实用医学杂志,2025,41(13):1952-1957,6.基金项目
国家自然科学基金资助项目(编号:82260609) （编号:82260609）
云南省基础研究专项(编号:202201AS070085) （编号:202201AS070085）
