时珍国医国药2025，Vol.36Issue(13)：2509-2514,6.DOI:10.70976/j.1008-0805.SZGYGY-2025-1316
基于舌脉象客观化的糖尿病前期中医综合干预方案的疗效评价研究
Study on the efficacy evaluation of comprehensive intervention plan of TCM on prediabetes based on objective evaluation of tongue and pulse conditions
摘要
Abstract
Objective To observe the changes in tongue and pulse indicators before and after the intervention of people with prediabe-tes,the effectiveness of comprehensive intervention plan of traditional Chinese medicine(TCM)was evaluated to provide an objective e-valuation method of TCM efficacy for the prevention and treatment of prediabetes.Methods 368 cases of prediabetes subjects were en-rolled and randomly divided into a treatment group with 201 cases and a control group with 167 cases.After one year of intervention,189 cases were finally included in the treatment group and 157 cases in the control group for analysis.The TDA-1 small tongue imaging de-vice and YJJ-101 pulse monitoring system were used to obtain tongue imaging parameters(ASM,ENT,MEAN,L,a,b)and pulse parameters(t1,h1,w,As,Ad,etc.),respectively.Simultaneously,glucose and lipid metabolism indicators(HbA1c,FINS,HOMA-IR,FFA)and safety indicators(ALT,BUN,Cr)were detected.Results After intervention,the treatment group showed a decreasing trend in glycated hemoglobin(HbA1c)levels compared to the control group.Both groups showed increased fasting insulin secretion lev-els and HOMA-IR,with statistical differences in the control group(P＜0.05).Both groups showed an increase in fasting free fatty acids(FFA),with a significant statistical difference in the control group(P＜0.05).The FFA level in the treatment group was lower than in the control group(P＜0.05).In terms of tongue textue,the Levels of L,a,and b(ZhiL,Zhia,Zhib)in both groups increased,while the tongue textue ASM(ZhiASM)decreased and the tongue textue ENT and MEAN(ZhiENT,ZhiMEAN)increased(P＜0.05).In terms of tongue Coating,the levels of L,a,b(taiL,taia,taib)increased in both groups,While the tongue coating ASM(TaiASM)de-creased and the tongue coating ENT and MEAN(taiENT,taiMEAN)increased(P＜0.05).In terms of pulse,the treatment group showed a decrease in w and w/t,while the control group showed an increase in w and w/t(P＜0.05).The control group showed an increase in h1,h1/t1,s,and As(P＜0.05).Conclusion The comprehensive intervention plan of TCM can improve the glucose and lipid metabo-lism of prediabetes subjects,delay the progress of insulin resistance,and reflect the corresponding changes in the objective indicators of tongue and pulse conditions.Objective indicators of tongue and pulse can be used as a potential method to evaluate the efficacy of TCM in the treatment of diabetes.关键词
糖尿病前期/舌象客观化/脉象客观化/中医综合干预方案Key words
Prediabetes/Objective evaluation of tongue conditions/Objective evaluation of pulse conditions/Comprehensive in-tervention plan of TCM分类
医药卫生引用本文复制引用
马绮娴,韩诗雨,黄慧,田静,韩煦,陈清光,陆灏..基于舌脉象客观化的糖尿病前期中医综合干预方案的疗效评价研究[J].时珍国医国药,2025,36(13):2509-2514,6.基金项目
国家自然科学基金(82104738) （82104738）
上海市科委科研计划(22S21900400) （22S21900400）
上海市中医临床重点实验室项目(20DZ2272200) （20DZ2272200）
浦东新区卫生健康委员会联合攻关项目(PW2024D-12) （PW2024D-12）
上海中医药大学标准化研究课题(SHUTCMBZH-2024BZH05) （SHUTCMBZH-2024BZH05）
