时珍国医国药2025，Vol.36Issue(14)：2614-2621,8.DOI:10.70976/j.1008-0805.SZGYGY-2025-1403
温阳填精解郁方改善肾阳虚抑郁大鼠腓肠肌重量的机制研究
Mechanism of Wenyang Tianjing Jieyu Decoction(温阳填精解郁方)in ameliorating gastrocne-mius muscle weight in rats with kidney yang deficiency depression
摘要
Abstract
Objective To explore the pathological mechanisms underlying reduced gastrocnemius muscle(GM)weight in rats with kid-ney yang deficiency depression,and to elucidate the therapeutic pathways by which Wenyang Tianjing Jieyu Decoction(温阳填精解郁方,WTJD)restores muscle weight.Methods 40 male SD rats were randomly divided into the normal group,model group,fluoxetine group,WTJD high-dose and medium-dose groups.The rat model of kidney yang deficiency depression was established in the 4 groups except the normal group,and the corresponding drugs were given after the model was successfully established.The behavior of rats in each group was evaluated before and after treatment,and the pathological changes of GM,PGC-1αprotein expression,IL-6,IL-17A,TNF-α,IL-1β,IFN-γ,IL-4,IL-10,TGF-β1,MDA levels and SOD activity were measured.Results The rats with kidney yang deficiency depression showed lazy behavior tendency and the weight gain slowed down,the weight of GM was lower than that of normal rats,and the muscle fibers were arranged disorderly and thin with inflammatory infiltration.Further detection showed that the level of PGC-1α in GM of rats with kidney yang deficiency depression was decreased,with low inflammation and oxidative stress.WTJD could increase the weight of GM in rats with kidney yang deficiency depression,ameliorate the pathological conditions of GM fiber ar-rangement disorder and inflammatory infiltration,increase the expression of PGC-1α,and alleviate the low-grade inflammation and ox-idative stress of GM.Conclusion Gastrocnemius inflammation and oxidative stress may be the potential pathological basis of muscle re-duction in rats with kidney yang deficiency depression.WTJD can up-regulate the expression of PGC-1α in GM,alleviate low-grade inflammation,inhibit oxidative stress,thus increasing the weight of GM.关键词
肾阳虚/肌肉减少/抑郁/炎症/氧化应激/温阳填精解郁方Key words
Wenyang Tianjing Jieyu Decoction(温阳填精解郁方)/Kidney yang deficiency/Sarcopenia/Depression/Inflam-mation/Oxidative stress分类
医药卫生引用本文复制引用
张甜,王祎,郭珮,夏修文,李炜弘..温阳填精解郁方改善肾阳虚抑郁大鼠腓肠肌重量的机制研究[J].时珍国医国药,2025,36(14):2614-2621,8.基金项目
国家自然科学基金(81873204) （81873204）
四川省科学技术计划(2021YFS0040) （2021YFS0040）
